Clinical outcomes among patients with head and neck cancer treated by intensity-modulated radiotherapy with and without adaptive replanning
Clinical outcomes among patients with head and neck cancer treated by intensity-modulated radiotherapy with and without adaptive replanning
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DOI：
10.1002/hed.23477
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发表时间：
2014-11-01
影响因子：
2.9
通讯作者：
Purdy, James A.
中科院分区：
文献类型：
--
作者：
Chen, Allen M.;Daly, Megan E.;Purdy, James A.
BackgroundThe本研究的目的是确定自适应重新计划对头颈部cancer. MethodsThirteen例患者的临床结果的影响，这些患者接受调强放疗（IMRT）治疗，每日影像引导下，新诊断的头颈部鳞状细胞癌的中位剂量为66戈伊（范围，60-74戈伊）。在这317例患者中，51（16%）进行了自适应放疗与修改的原始IMRT中途在treatment.ResultsThe 2年的局部区域控制与自适应重新规划治疗的患者为88%，而没有治疗的患者为79%（p = .01）。局部区域复发的中位时间为7个月（范围，3-15个月），所有的失败发生在高剂量计划靶区（PTV）。结论虽然使用常规重新规划可能是没有必要的，我们的研究结果表明，在适当选择的患者显着的好处。(c)2014 Wiley Periodicals，Inc.头颈部36：1541-1546，2014
BackgroundThe purpose of this study was to determine the effect of adaptive replanning on clinical outcome among patients treated by intensity-modulated radiotherapy (IMRT) for head and neck cancer.MethodsThree hundred seventeen patients underwent IMRT with daily image-guidance for newly diagnosed squamous cell carcinoma of the head and neck to a median dose of 66 Gy (range, 60-74 Gy). Of these 317 patients, 51 (16%) underwent adaptive radiotherapy with modification of the original IMRT midway during treatment.ResultsThe 2-year local-regional control was 88% for patients treated with adaptive replanning compared with 79% for patients treated without (p = .01). The median time to local-regional recurrence for the 4 patients treated by adaptive radiotherapy was 7 months (range, 3-15 months) with all failures occurring within the high-dose planning target volume (PTV).ConclusionAlthough the use of routine replanning is probably not necessary, our findings do suggest a significant benefit in appropriately selected patients. (c) 2014 Wiley Periodicals, Inc. Head Neck 36: 1541-1546, 2014