Changes of serum midkine as a dynamic prognostic factor to monitor disease status in papillary thyroid cancer.
Changes of serum midkine as a dynamic prognostic factor to monitor disease status in papillary thyroid cancer.
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血清中期因子的变化作为监测甲状腺乳头状癌疾病状态的动态预后因素
DOI：
10.1097/md.0000000000012242
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发表时间：
2018-09
期刊：
影响因子：
1.6
通讯作者：
Wang X
中科院分区：
文献类型：
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作者：
Li N;Zhang C;Meng Z;Xu K;He X;Yu Y;Jia Q;Li X;Liu X;Wang X
摘要本研究旨在探讨中期因子（MK）动态变化对甲状腺乳头状癌（PTC）术后131I治疗的监测价值。评价了初始131 I消融治疗（MK 1）以及之后10至12个月（MK 2）时的MK浓度。并比较甲状腺球蛋白（Tg）的动态变化（Tg 1和Tg 2）。排除MK影响合并症和甲状腺球蛋白抗体阳性的患者。酶联免疫吸附试验测定MK浓度。共纳入241例PTC患者（男36例，女205例），随访期间有55例转移（男8例，女47例）。考克斯回归分析显示，在TSH刺激下，Tg2较Tg1降低，但不低于1.0ng/mL时，发生转移的危险性是Tg2降低至最佳水平时的12.554倍。如果Tg 2增加，则风险增加19.461倍。至于MK，如果MK 2水平降低（与MK 1相比），但未达到正常水平，则转移的风险为3.006。如果MK2水平升高，发生转移的可能性为5.030。我们的研究结果表明，MK可能被用作PTC的疾病监测生物标志物，虽然不如Tg。
Abstract This study aimed to investigate the value of dynamic changes of midkine (MK) to monitor post-surgical patients with papillary thyroid cancer (PTC) who were managed with 131I therapies. MK concentration at initial 131I ablation therapy (MK1) as well as 10 to 12 months thereafter (MK2) was evaluated. And the dynamic changes of thyroglobulin (Tg) were compared (Tg1 and Tg2). Patients with MK influencing co-morbidities and with positive thyroglobulin antibodies were excluded. Concentrations of MK were measured by enzyme-linked immunosorbent assay. There were 241 PTC patients (36 males, 205 females) enrolled, 55 cases had metastases (8 males, 47 females) during their follow-up. Cox regression showed if Tg2 decreased (compared with Tg1), but not to less than 1.0ng/mL under TSH stimulation, the risk of metastases was 12.554 times more than if it could decrease to the optimal level. If Tg2 increased, the risk is 19.461 times higher. As for MK, if MK2 level decreased (compared with MK1), but not to a normal level, the risk of metastases is 3.006. If MK2 level increased, it would be 5.030 likely to had metastases. Our results indicated that MK could potentially be used as a disease monitoring biomarker for PTC, although inferior to Tg.
DOI：
10.1186/1755-7682-3-12
发表时间：
2010-06-21
期刊：
International archives of medicine
影响因子：
--
作者：
Matsui T;Ichihara-Tanaka K;Lan C;Muramatsu H;Kondou T;Hirose C;Sakuma S;Muramatsu T
通讯作者：
Muramatsu T