Successful Salvage of Very Early Relapse in Pediatric Acute Lymphoblastic Leukemia With Inotuzumab Ozogamicin and HLA-haploidentical Peripheral Blood Stem Cell Transplantation With Posttransplant Cyclophosphamide
Successful Salvage of Very Early Relapse in Pediatric Acute Lymphoblastic Leukemia With Inotuzumab Ozogamicin and HLA-haploidentical Peripheral Blood Stem Cell Transplantation With Posttransplant Cyclophosphamide
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使用 Inotuzumab Ozogamicin 和移植后环磷酰胺的 HLA-半相合外周血干细胞移植成功挽救小儿急性淋巴细胞白血病极早期复发
DOI：
10.1097/mph.0000000000002079
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Kawano Yoshifumi
中科院分区：
文献类型：
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作者：
Abematsu Takanari;Nishikawa Takuro;Nakagawa Shunsuke;Kodama Yuichi;Okamoto Yasuhiro;Kawano Yoshifumi
在此，我们描述了一个14岁的女性患者与B细胞前体急性淋巴细胞白血病谁复发的早期巩固。在1个周期的inotuzumab ozogamicin治疗后获得了最小残留疾病阴性完全缓解。在清髓性预处理方案后，她接受了HLA半相合外周血干细胞移植。移植后给予环磷酰胺、他克莫司和吗替麦考酚酯预防移植物抗宿主病。23个月时，她完全缓解。虽然在儿童中使用inotuzumab ozogamicin，然后进行单倍体相合外周血干细胞移植和移植后环磷酰胺，但这种策略可能是治疗儿童难治性急性淋巴细胞白血病的有效方法。
Herein, we describe a 14-year-old female patient with B-cell precursor acute lymphoblastic leukemia who relapsed in early consolidation. Minimal residual disease-negative complete remission was obtained after 1 cycle of inotuzumab ozogamicin therapy. She underwent HLA-haploidentical peripheral blood stem cell transplantation after a myeloablative conditioning regimen. Posttransplant cyclophosphamide, tacrolimus, and mycophenolate mofetil were administered for the prophylaxis of graft-versus-host disease. At 23 months, she was in complete remission. Although the administration of inotuzumab ozogamicin followed by haploidentical peripheral blood stem cell transplantation with posttransplant cyclophosphamide has been limited in children, this strategy may be an effective treatment for pediatric refractory acute lymphoblastic leukemia.