Linkage of A-to-I RNA Editing in Metazoans and the Impact on Genome Evolution.
Linkage of A-to-I RNA Editing in Metazoans and the Impact on Genome Evolution.
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后生动物中 A 到 I RNA 编辑的联系及其对基因组进化的影响
DOI：
10.1093/molbev/msx274
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发表时间：
2018-01-01
影响因子：
10.7
通讯作者：
Lu J
中科院分区：
文献类型：
--
作者：
Duan Y;Dou S;Zhang H;Wu C;Wu M;Lu J
腺苷到肌苷（A-to-I）RNA编辑组已被系统地描述在各种后生动物物种中，许多编辑位点被发现成簇。然而，目前还不清楚这些成簇的编辑位点是否倾向于在相同的RNA分子中连接。通过采用一种最初设计用于检测DNA突变连锁不平衡的方法，我们检查了10种后生动物的编辑组，并在果蝇和头足类动物中检测到广泛的编辑连锁。这两个进化枝中普遍存在的编辑联系，其中许多在密切相关的物种之间是保守的，可能与适应性蛋白质组学编码有关，是以基因组进化为代价通过自然选择维持的。尽管如此，在蠕虫和人类中，我们只检测到了适度比例的连锁编辑事件，其中大多数是不保守的。此外，蠕虫和人类编码区的编辑联系可能总体上是有害的，这推动了DNA位点的进化以逃避混杂编辑。总之，我们的研究结果表明，在后生动物进化过程中，A到I编辑的连锁景观已经演变。本研究还表明，在阐明RNA编辑的功能后果时，应考虑编辑的联系。
The adenosine-to-inosine (A-to-I) RNA editomes have been systematically characterized in various metazoan species, and many editing sites were found in clusters. However, it remains unclear whether the clustered editing sites tend to be linked in the same RNA molecules or not. By adopting a method originally designed to detect linkage disequilibrium of DNA mutations, we examined the editomes of ten metazoan species and detected extensive linkage of editing in Drosophila and cephalopods. The prevalent linkages of editing in these two clades, many of which are conserved between closely related species and might be associated with the adaptive proteomic recoding, are maintained by natural selection at the cost of genome evolution. Nevertheless, in worms and humans, we only detected modest proportions of linked editing events, the majority of which were not conserved. Furthermore, the linkage of editing in coding regions of worms and humans might be overall deleterious, which drives the evolution of DNA sites to escape promiscuous editing. Altogether, our results suggest that the linkage landscape of A-to-I editing has evolved during metazoan evolution. This present study also suggests that linkage of editing should be considered in elucidating the functional consequences of RNA editing.
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影响因子：
3.3
作者：
Gu, Tongjun;Gatti, Daniel M.;Churchill, Gary A.
通讯作者：
Churchill, Gary A.
影响因子：
3.5
作者：
Borchert GM;Gilmore BL;Spengler RM;Xing Y;Lanier W;Bhattacharya D;Davidson BL
通讯作者：
Davidson BL
A-I 编辑在果蝇中的适应
影响因子：
4.5
作者：
Duan Y;Dou S;Luo S;Zhang H;Lu J
通讯作者：
Lu J
DOI：
10.1126/science.1212795
发表时间：
2012-02-17
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Garrett S;Rosenthal JJ
通讯作者：
Rosenthal JJ
识别广泛的超编辑人类RNA。
影响因子：
4.5
作者：
Carmi S;Borukhov I;Levanon EY
通讯作者：
Levanon EY