Xenimanadins A-D, a family of xenicane diterpenoids from the Indonesian soft coral Xenia sp.
Xenimanadins A-D, a family of xenicane diterpenoids from the Indonesian soft coral Xenia sp.
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DOI：
10.1016/j.tet.2008.01.120
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发表时间：
2008-03-31
期刊：
影响因子：
2.1
通讯作者：
Cerrano, Carlo
中科院分区：
文献类型：
--
作者：
Fattorusso, Ernesto;Romano, Adriana;Cerrano, Carlo
从印度尼西亚软珊瑚Xenia sp.中分离出四种新的xenicane二萜类化合物xenimanadins A-D（1-4），其特征是具有不寻常的2，6-二甲氧基四氢吡喃官能团，以及三种已知的xeniolide。通过对NMR数据的广泛解释和应用改良的Mosher方法，已确定了这些代谢物的立体结构。针对肿瘤细胞系测试了Xenimanadins，揭示了关于xenicane二萜类化合物的细胞毒性潜力的细节。(c)2008爱思唯尔有限公司保留所有权利。
Four novel xenicane diterpenoids, xenimanadins A-D (1-4), characterized by the unusual 2,6-dimethoxytetrahydropyran functionality, have been isolated from the Indonesian soft coral Xenia sp., together with three known xeniolides. The stereostructure of these metabolites has been established through extensive interpretation of NMR data and application of the modified Mosher method. Xenimanadins were tested against tumor cell lines, revealing details about the cytotoxic potential of xenicane diterpenoids. (c) 2008 Elsevier Ltd. All rights reserved.