ORAL BETA-CAROTENE CAN INCREASE THE NUMBER OF OKT4+ CELLS IN HUMAN-BLOOD
ORAL BETA-CAROTENE CAN INCREASE THE NUMBER OF OKT4+ CELLS IN HUMAN-BLOOD
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DOI：
10.1016/0165-2478(85)90036-7
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发表时间：
1985-01-01
影响因子：
4.4
通讯作者：
MILLER, RG
中科院分区：
文献类型：
--
作者：
ALEXANDER, M;NEWMARK, H;MILLER, RG
口服剂量的β-对正常人志愿者给予胡萝卜素（180 mg/天）2周，7天后显著增加OKT 4+（辅助/诱导T细胞）的频率，14天后显著增加OKT 3+（所有T细胞）的频率。与未处理的对照相比，OKT 8+细胞的频率不受影响。血浆β-胡萝卜素在整个研究中显著升高。维生素A的血浆水平在第7天和第14天略微（但显著）升高。未观察到毒性。口服β-胡萝卜素治疗可能是增强T4+淋巴细胞的临床有效手段。
Oral doses of .beta.-carotene (180 mg/day) given for 2 wk to normal human volunteers significantly increased the frequency of OKT4+(helper/inducer T cells) after 7 days and of OKT3+ (all T cells) after 14 days. The frequency of OKT8+ cells was unaffected, as compared to untreated controls. Plasma levels of .beta.-carotene were markedly elevated throughout the study. Plasma levels of vitamin A were slightly (but significantly) elevated on days 7 and 14. No toxicity was observed. Oral .beta.-carotene treatment may be a clinically effective means of enhancing T4+ lymphocytes.