The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.
The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.
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白三烯受体 CysLT1 和 5-脂氧合酶在结肠癌中表达上调。
DOI：
10.1007/978-1-4419-9194-2_43
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发表时间：
2003
影响因子：
--
通讯作者：
A. Sjölander
中科院分区：
文献类型：
--
作者：
C. K. Nielsen;J. Ohd;K. Wikström;R. Massoumi;S. Paruchuri;M. Juhas;A. Sjölander
花生四烯酸的代谢产物与炎症、癌症和哮喘等病理状态密切相关。Sheng等[7]发现考克斯-2在结肠癌组织和肿瘤细胞系中上调，表明考克斯-2参与结肠癌。这得到了研究的支持，研究表明，接受非甾体抗炎药（考克斯-2抑制剂）治疗的患者结肠癌发生率较低[8]。当用LTD 4或LTB 4刺激非转化的肠上皮细胞系Int 407时，我们观察到考克斯-2在膜组分中的积累以及前列腺素E2的产生增加[5]。用考克斯-2抑制剂NS-398处理这些细胞会引起细胞凋亡，这种作用可以被LTD 4 [5]或LT B 4 [4]阻止。当在存在或不存在NS-398的情况下测定LTD 4或LTB 4的细胞活力时，获得了类似的结果[4，5]。结果表明，这些白细胞三烯可以抑制NS-398诱导的肠细胞凋亡。
The metabolites of arachidonic acid are well connected to pathological situations such as inflammation, cancer and asthmA. Sheng et al. [7] found that COX-2 is upregulated in colon cancer tissue and tumor cell lines indicating that COX-2 is involved in colon cancer. This is supported by studies showing that patients treated with nonsteroidal anti-inflammatory drugs, inhibitors of COX-2, exhibit a lower frequency of colon cancer [8]. When the non-transformed intestinal epithelial cell line, Int 407 was stimulated with LTD4 or LTB4 we observed an accumulation of COX-2 in membrane fractions as well as an increased production of prostaglandin E2 [5]. Treatment of these cells with the COX-2 inhibitor NS-398 caused apoptosis and this effect could be prevented by LTD4 [5] or LTB4 [4]. Similar results were obtained when cell viability with LTD4 or LTB4 in the presence or absence of NS-398 was assayed [4,5]. The results demonstrate that these leukotrienes can suppress the NS-398 induced apoptosis in intestinal cells.
影响因子：
11.2
作者：
M. Krajewska;S. Moss;S. Krajewski;K. Song;P. Holt;John Calvin Reed
通讯作者：
M. Krajewska;S. Moss;S. Krajewski;K. Song;P. Holt;John Calvin Reed