Epidemiologic studies of environmental exposures in Parkinson's disease
Epidemiologic studies of environmental exposures in Parkinson's disease
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DOI：
10.1016/j.jns.2007.06.024
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发表时间：
2007-11-15
影响因子：
4.4
通讯作者：
Tranchant, Christine
中科院分区：
文献类型：
--
作者：
Elbaz, Alexis;Tranchant, Christine
帕金森病（Parkinson's disease，PD）是帕金森综合征最常见的病因，也是继阿尔茨海默病（Alzheimer's disease，AD）之后最常见的神经退行性疾病。由于西方人口的老龄化，越来越多的人将在未来受到PD的影响，既没有治愈性治疗，也没有预防措施。PD是一种多因素疾病，是环境因素和遗传易感性共同作用的结果。年龄增加和男性似乎与PD风险增加相关。此外，最近的流行病学研究已经确定了影响PD风险的环境暴露。本文综述了PD环境病因的流行病学证据，我们将重点关注两个一直与PD相关的环境暴露-吸烟和农药暴露-并将简要总结其他暴露的结果。了解这些流行病学关联的机制是了解这种神经退行性疾病病因的重要步骤，理想情况下，开发神经保护药物。(c)2007 Elsevier B.V保留所有权利。
Parkinson's disease (PD) is the most common cause of the parkinsonian syndromes and the most frequent neurodegenerative disease after Alzheimer's disease. Because of the ageing of Western populations, an increasing number of persons will be affected with PD in the future and neither curative treatments nor preventive measures have been identified. PD is considered as a multifactorial disease, resulting from the effect of environmental factors and genetic susceptibility. Increasing age and male sex appear to be associated with an increased risk of PD. In addition, recent epidemiological studies have identified environmental exposures that influence the risk of PD. This review provides an overview of the epidemiologic evidence for environmental etiologies in PD; we will focus on two environmental exposures that have been quite consistently associated with PD - cigarette smoking and pesticide exposure - and will summarize briefly the findings for other exposures. Understanding the mechanisms underlying these epidemiological associations is an essential step for the understanding of the etiology of this neurodegenerative condition and, ideally, to develop neuroprotective drugs. (c) 2007 Elsevier B.V All rights reserved.