Desmocollin switching in colorectal cancer.
Desmocollin switching in colorectal cancer.
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DOI：
10.1038/sj.bjc.6603453
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发表时间：
2006-11-20
影响因子：
8.8
通讯作者：
Chidgey M
中科院分区：
文献类型：
--
作者：
Khan K;Hardy R;Haq A;Ogunbiyi O;Morton D;Chidgey M
桥粒粘附蛋白是细胞间粘附分子桥粒钙粘蛋白家族的成员。它们是桥粒的基本组成部分，桥粒是细胞间连接，在维持上皮和心肌组织完整性方面发挥关键作用。在人类中，已经描述了三种桥粒柯林斯（Dsc 1，Dsc 2和Dsc 3）。桥粒柯林斯表现出组织特异性的表达模式，只有Dsc 2在正常结肠上皮中表达。我们已经发现在散发性结直肠腺癌中桥粒蛋白之间的转换，Dsc 2蛋白的减少（在通过免疫组织化学分析的8/16个样品中）伴随着Dsc 1（16/16）和Dsc 3（7/16）的从头表达。通过对另外16个样品的蛋白质印迹法获得了类似的结果。Dsc 2 mRNA没有变化，但Dscs 1和3的从头表达伴随着信息水平的增加。在结肠炎背景下的结直肠腺癌中也发现Dsc 2缺失（8/19）和Dsc 1（11/19）和Dsc 3（6/19）的重新表达。这些数据提高了桥粒蛋白转换在结直肠癌发展中发挥重要作用的可能性。
The desmocollins are members of the desmosomal cadherin family of cell–cell adhesion molecules. They are essential constituents of desmosomes, intercellular junctions that play a critical role in the maintenance of tissue integrity in epithelia and cardiac muscle. In humans, three desmocollins (Dsc1, Dsc2 and Dsc3) have been described. The desmocollins exhibit tissue-specific patterns of expression; only Dsc2 is expressed in normal colonic epithelium. We have found switching between desmocollins in sporadic colorectal adenocarcinoma with a reduction in Dsc2 protein (in 8/16 samples analysed by immunohistochemistry) being accompanied by de novo expression of Dsc1 (16/16) and Dsc3 (7/16). Similar results were obtained by western blotting of a further 16 samples. No change was found in Dsc2 mRNA, but de novo expression of Dscs 1 and 3 was accompanied by increased message levels. Loss of Dsc2 (8/19) and de novo expression of Dsc1 (11/19) and Dsc3 (6/19) was also found in colorectal adenocarcinomas on a background of colitis. The data raise the possibility that switching of desmocollins could play an important role in the development of colorectal cancer.
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影响因子：
7.8
作者：
Chidgey, M;Brakebusch, C;Gustafsson, E;Cruchley, A;Hail, C;Kirk, S;Merritt, A;North, A;Tselepis, C;Hewitt, J;Byrne, C;Fassler, R;Garrod, D
通讯作者：
Garrod, D
DOI：
10.1186/bcr1273
发表时间：
2005
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Oshiro MM;Kim CJ;Wozniak RJ;Junk DJ;Muñoz-Rodríguez JL;Burr JA;Fitzgerald M;Pawar SC;Cress AE;Domann FE;Futscher BW
通讯作者：
Futscher BW
影响因子：
7.5
作者：
Aust, DE;Terdiman, TP;Waldman, FM
通讯作者：
Waldman, FM
影响因子：
8.8
作者：
COLLINS, JE;TAYLOR, I;GARROD, DR
通讯作者：
GARROD, DR
影响因子：
7.8
作者：
PENN, EJ;BURDETT, IDJ;REES, DA
通讯作者：
REES, DA