Pharmacokinetics and effects on the renin-angiotensin system of ramipril in elderly patients.
Pharmacokinetics and effects on the renin-angiotensin system of ramipril in elderly patients.
复制标题
雷米普利在老年患者中的药代动力学及其对肾素-血管紧张素系统的影响。
DOI：
10.1016/0002-9149(87)90049-x
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
S. Ball
中科院分区：
文献类型：
--
作者：
W. Gilchrist;K. Beard;P. Manhem;E. M. Thomas;J. Robertson;S. Ball
转换酶抑制剂可能会越来越频繁地在老年患者中使用。在一组8名老年志愿者（平均年龄77岁，范围61至84岁）中研究了一种新型长效非巯基转换酶抑制剂雷米普利的药代动力学及其对血压、血浆肾素活性和血管紧张素II浓度的影响。与年轻志愿者（年龄范围21至30岁）相比，尽管通过血清肌酐和尿素浓度评估的肾功能明显正常，但该组中由母体药物形成的活性二酸的循环浓度始终较高。老年受试者的初始剂量应较低。这项研究强调了将从年轻志愿者那里获得的数据仔细外推到老年受试者身上的重要性。
Converting enzyme inhibitors are likely to be prescribed with increasing frequency in elderly patients. The pharmacokinetics of ramipril, a new potent long-acting non-sulphydryl converting enzyme inhibitor, and its effects on blood pressure, plasma renin activity and angiotensin II concentrations were studied in a group of 8 elderly volunteers (mean age 77, range 61 to 84). Circulating concentrations of the active diacid formed from its parent drug were consistently higher in this group despite apparently normal renal function, assessed by serum creatinine and urea concentrations, compared with younger volunteers (age range 21 to 30). The initial dose of ramipril should be lower in older subjects. The study emphasizes the importance of careful extrapolation of data obtained from young volunteers to older subjects.