[3H] dynorphin binding to guinea pig and rat brain.
[3H] dynorphin binding to guinea pig and rat brain.
复制标题
[3H] 强啡肽与豚鼠和大鼠大脑结合。
DOI：
10.1016/0024-3205(83)90499-x
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发表时间：
1983
期刊：
影响因子：
6.1
通讯作者：
Akil,H
中科院分区：
文献类型：
--
作者：
Young,E;Walker,JM;Houghten,R;Akil,H
[~H]强啡肽可与大鼠和豚鼠的脑结合，特异性结合约50%。多种阿片受体类型的结合特征支持强啡肽在豚鼠中的kappa选择性。然而，在大鼠脑中，相当大比例的[~3H]强啡肽结合被吗啡取代，这表明存在u和kappa成分。因此，在大鼠体内，强啡肽可能同时对Mu和kappa受体产生影响。
Abstract [3 H] Dynorphin can be shown to bind to the brains of both rat and guinea pigs with approximately 50% specific binding. Characterization of the binding in terms of multiple opiate receptor types supports the kappa selectivity of dynorphin in guinea pig. However, in rat brain, a substantial proportion of the [3 H] dynorphin binding is displaced by morphine, suggesting a mu as well as kappa component. Consequently, in rat, dynorphin may show effects at both mu and kappa receptors in vivo.