Destruction and Construction: Application of Dearomatization Strategy in Aromatic Carbon-Nitrogen Bond Functionalization
Destruction and Construction: Application of Dearomatization Strategy in Aromatic Carbon-Nitrogen Bond Functionalization
复制标题
破坏与构建：脱芳构化策略在芳香碳氮键功能化中的应用
DOI：
10.1002/anie.201508161
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Fan Renhua
中科院分区：
文献类型：
--
作者：
Wang Shuo-En;Wang Linfei;He Qiuqin;Fan Renhua
通过芳族碳-氮键的官能化形成碳-碳键是芳香族分子合成中极具吸引力的合成策略。本文报道了一种新的芳香碳氮键官能化反应，该反应采用一种简单的脱芳构化策略。通过该过程，对位取代的苯胺在一系列官能化芳族分子的构建中充当潜在的芳基源，例如季碳中心、α-酮基酯和醛。
The formation of carbon–carbon bonds through the functionalization of aromatic carbon–nitrogen bonds is a highly attractive synthetic strategy in the synthesis of aromatic molecules. In this paper, we report a novel aromatic carbon–nitrogen bond functionalization reaction by using a simple dearomatization strategy. Through this processpara‐substituted anilines serve as a potential aryl source in the construction of a range of functionalized aromatic molecules, such as quaternary carbon centers, α‐keto esters, and aldehydes.