Influenza-like viral illnesses and flare-ups of fibrodysplasia ossificans progressiva
Influenza-like viral illnesses and flare-ups of fibrodysplasia ossificans progressiva
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DOI：
10.1097/01.blo.0000129557.38803.26
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发表时间：
2004-06-01
影响因子：
4.2
通讯作者：
Kaplan, FS
中科院分区：
文献类型：
--
作者：
Scarlett, RF;Rocke, DM;Kaplan, FS
进行性骨化性纤维发育不良最常由软组织创伤引发。在观察到两个同父异母的姐妹培养证实感染了B型流感病毒后，严重的进行性骨化性纤维发育不良发作，我们假设流感样病毒疾病也可以引发进行性骨化性纤维发育不良发作。为了解决这一假设，我们设计了一份问卷调查，以评估在2000年至2001年流感季节期间，进行性骨化性纤维发育不良患者是否出现流感症状，以及这些症状是否与病情的突然发作相关。该调查问卷被发送给全球进行性骨化性纤维发育不良患者。在接受调查的264名患者中，123名（47%）有反应。该调查显示，在流感样病毒性疾病期间，进行性骨化性纤维发育不良疾病发作的风险至少增加了三倍，甚至可能更多。调查数据强烈支持这一假设，即流感样病毒性疾病与进行性骨化性纤维发育不良患者的疾病发作有关。流感样病毒性疾病可能是以前未被认识到的肌肉损伤的来源，导致异位骨化和永久性丧失的流动性，在这些患者。这些发现对于理解和预防遗传上易患进行性异位骨化的患者人群中疾病活动的环境触发因素具有重要意义。
Flare-ups of fibrodysplasia ossificans progressiva are most commonly triggered by soft tissue trauma. After observing severe flare-ups of fibrodysplasia ossificans progressiva in two half-sisters with culture-confirmed influenza B infections, we hypothesized that influenza-like viral illnesses also can trigger fibrodysplasia ossificans progressiva flare-ups. To address this hypothesis, we designed a questionnaire to assess whether patients with fibrodysplasia ossificans progressiva experienced influenza symptoms during the 2000 to 2001 influenza season, and whether these symptoms were correlated with flare-ups of the condition. The questionnaire was sent to patients with fibrodysplasia ossificans progressiva worldwide. Of the 264 patients surveyed, 123 (47%) responded. The survey revealed that the risk of a disease flare-up of fibrodysplasia ossificans progressiva during an influenza-like viral illness was increased at least threefold and possibly much more. The survey data strongly supported the hypothesis that influenza-like viral illnesses are associated with disease flare-ups in patients who have fibrodysplasia ossificans progressiva. Influenza-like viral illnesses may be a source of previously unrecognized muscle injury leading to heterotopic ossification and permanent loss of mobility in these patients. These findings have important implications for understanding and preventing environmental triggers of disease activity in this population of patients genetically susceptible to progressive heterotopic ossification.