Spine-tingling excitement from glutamate receptors.
Spine-tingling excitement from glutamate receptors.
复制标题
谷氨酸受体带来令人脊椎发麻的兴奋。
DOI：
10.1126/stke.2102003pe53
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Huettner,JamesE
中科院分区：
文献类型：
--
作者：
Huettner,JamesE
嗜电离性谷氨酸受体通过在细胞膜上形成阳离子选择性孔来刺激神经细胞。然而，最近的研究提供了证据，证明谷氨酸受体的非典型信号调节树突棘的产生和维持，树突棘是接受大多数中枢兴奋性突触的短产物。脊柱形成的控制涉及AMPA （α-氨基-3-羟基-5-甲基异恶唑-4-丙酸）受体GluR2亚基的氨基端胞外结构域。与该结构域的相互作用如何向下游效应器发出信号仍有待阐明，但通过通道的离子通量可能不需要。这个观点讨论了GluR2对脊柱的调节可能是越来越多的案例之一，在这些案例中，嗜离子性谷氨酸受体可以引发传统上归因于代谢受体的生化变化。这表明，与特定谷氨酸受体亚基接触的蛋白质可能直接感知激动剂结合产生的构象变化。
Ionotropic glutamate receptors excite nerve cells by forming cation-selective pores in the membrane. Recent work, however, provides evidence that atypical signaling by glutamate receptors regulates the production and maintenance of dendritic spines, the short outgrowths that receive most central excitatory synapses. The control of spine formation involves the amino-terminal extracellular domain of the GluR2 subunit of AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptors. How interactions with this domain elicit signals to downstream effectors remains to be elucidated, but ion flux through the channel may not be required. This Perspective discusses the possibility that regulation of spines by GluR2 may be one of a growing collection of cases in which ionotropic glutamate receptors can elicit biochemical changes that are conventionally attributed to metabotropic receptors. It is suggested that proteins in contact with specific glutamate receptor subunits may directly sense the conformational changes produced by agonist binding.