Parabrachial gustatory neural responses to monosodium glutamate ingested by awake rats.
Parabrachial gustatory neural responses to monosodium glutamate ingested by awake rats.
复制标题
清醒大鼠摄入谷氨酸钠后臂旁味觉神经反应。
DOI：
10.1016/0031-9384(91)90209-7
复制
发表时间：
1991
影响因子：
2.9
通讯作者：
Norgren,R
中科院分区：
文献类型：
--
作者：
Nishijo,H;Ono,T;Norgren,R
A sample of 41 gustatory neurons isolated in the parabrachial nuclei of awake, behaving rats was tested with sapid solutions of 0.1 M monosodium glutamate (MSG), 0.5 mM of guanosine 5′-monophosphate (GMP), and a mixture of MSG and GMP as well as with 0.3 M sucrose, 0.1 M NaCl, 0.01 M citric acid, and 0.0001 M QHCl. Interneuronal correlation coefficients and factor analysis indicated that both the sodium cation and glutamic anion contributed to the activity elicited by MSG. Guanosine potentiated the responses to MSG, but only in neurons that also responded to sucrose. These results suggest that the gustatory contribution to the flavor denoted by the Japanese word “umami” may be mediated, in part, by neurons that also respond to chemicals described by humans as sweet.
