Evidence for a role of developmental genes in the origin of obesity and body fat distribution
Evidence for a role of developmental genes in the origin of obesity and body fat distribution
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DOI：
10.1073/pnas.0601752103
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发表时间：
2006-04-25
影响因子：
11.1
通讯作者：
Kahn, CR
中科院分区：
文献类型：
--
作者：
Gesta, S;Blüher, M;Kahn, CR
肥胖，尤其是中心性肥胖，是一种与糖尿病和代谢紊乱的高风险发展相关的遗传性状。结合基因表达分析的脂肪细胞和前脂肪细胞含有馏分从腹腔内和皮下脂肪组织的小鼠显示协调仓库特定的差异，在胚胎发育和模式规范中涉及的多个基因的表达。这些差异是内在的，并在体外培养和分化过程中持续存在。在人类皮下脂肪组织与内脏脂肪组织中观察到发育基因表达的类似贮库特异性差异。此外，在人类中，一些基因表现出与体重指数和/或腰/臀比密切相关的表达变化。总之，这些数据表明，脂肪细胞及其前体在身体不同区域的遗传程序化发育差异在肥胖、体脂分布以及内部和皮下脂肪组织之间的潜在功能差异中起着重要作用。
Obesity, especially central obesity, is a hereditable trait associated with a high risk for development of diabetes and metabolic disorders. Combined gene expression analysis of adipocyte- and preadipocyte-containing fractions from intraabdominal and subcutaneous adipose tissue of mice revealed coordinated depot-specific differences in expression of multiple genes involved in embryonic development and pattern specification. These differences were intrinsic and persisted during in vitro culture and differentiation. Similar depot-specific differences in expression of developmental genes were observed in human subcutaneous versus visceral adipose tissue. Furthermore, in humans, several genes exhibited changes in expression that correlated closely with body mass index and/or waist/hip ratio. Together, these data suggest that genetically programmed developmental differences in adipocytes and their precursors in different regions of the body play an important role in obesity, body fat distribution, and potential functional differences between internal and subcutaneous adipose tissue.