Enantioselective Heck-type reaction catalyzed by tropos-Pd(II) complex with chiraphos ligand
Enantioselective Heck-type reaction catalyzed by tropos-Pd(II) complex with chiraphos ligand
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DOI：
10.1002/adsc.200505154
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发表时间：
2005-10-01
影响因子：
5.4
通讯作者：
Mikami, K
中科院分区：
文献类型：
--
作者：
Akiyama, K;Wakabayashi, K;Mikami, K
Pd(II)催化的不对称有机硼介导的Heck反应是在分子氧作为氧化剂的情况下进行的。Pd(OAc)(2)/(S，S)-手性催化剂具有较好的产率和对映体选择性。在平衡的两种可能的增量构象和波长构象中，该反应通过具有两个甲基的手性构象的X构象在二轴取向上进行。
The Pd(II)-catalyzed enantioselective organoboron-mediated Heck-type reaction is shown to proceed under molecular oxygen as an oxidant. The Pd(OAC)(2)/(S,S)-chiraphos catalyst gives good yield and the best enantioselectivity. Among the two possible delta- and lambda-conformations in equilibrium, this reaction proceeds via the X-conformation of chiraphos with the two methyl groups in a diaxial orientation.