Expression of the SOX10 gene during human development
Expression of the SOX10 gene during human development
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DOI：
10.1016/s0014-5793(98)00843-6
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发表时间：
1998-08-07
期刊：
影响因子：
3.5
通讯作者：
Goossens, M
中科院分区：
文献类型：
--
作者：
Bondurand, N;Kobetz, A;Goossens, M
SOX10 是 SOX 基因家族的新成员，是 Dom（显性巨结肠）小鼠和人类 Shah-Waardenburg 综合征中存在缺陷的转录因子。为了帮助揭示其在人类发育过程中的生理作用，我们通过 Northern 印迹和原位杂交研究了胚胎、胎儿和成人组织中的 SOX10 基因表达。与在小鼠中一样，人类SOX10基因本质上在有助于周围神经系统形成的神经嵴衍生物中表达，并且在成人中枢神经系统中表达。尽管如此，它在人类中的表达比在啮齿类动物中更广泛。 SOX10 表达的空间和时间模式支持神经嵴发育中的重要功能，(C) 1998 年欧洲生化协会联合会。
SOX10, a new member of the SOX gene family, is a transcription factor defective in the Dom (Dominant megacolon) mouse and in the human Shah-Waardenburg syndrome. To help unravel its physiological role during human development, we studied SOX10 gene expression in embryonic, fetal, and adult human tissues by Northern blot and in situ hybridization. As in mice, the human SOX10 gene was essentially expressed in the neural crest derivatives that contribute to the formation of the peripheral nervous system, and in the adult central nervous system, Nevertheless, it was more widely expressed in humans than in rodents. The spatial and temporal pattern of SOX10 expression supports an important function in neural crest development, (C) 1998 Federation of European Biochemical Societies.