Oxidative stress in systemic lupus erythematosus: relationship to disease activity and symptoms
Oxidative stress in systemic lupus erythematosus: relationship to disease activity and symptoms
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DOI：
10.1177/0961203306075802
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发表时间：
2007-01-01
期刊：
影响因子：
2.6
通讯作者：
Stein, C. M.
中科院分区：
文献类型：
--
作者：
Avalos, I.;Chung, C. P.;Stein, C. M.
氧化应激可能在系统性红斑狼疮(SLE)的发病机制中起一定作用。我们检验了氧化应激与狼疮疾病活动性和症状严重程度相关的假设。对95例系统性红斑狼疮患者和103例健康对照进行了尿F-2异前列腺素排泄量的测定，这是氧化应激的有效标志。结果测量包括SLEDAI和SLICC评分，修改后的健康评估问卷，疲劳严重程度量表(FSS)，以及疲劳、疼痛和总体疾病活动的视觉模拟评分(VAS)。比较患者和对照组的F-2异前列腺素排泄量，并探讨其与SLE临床变量的关系。狼疮患者F2异前列腺素排泄量(2.7+/-2.3 ng/mgCr)与对照组(2.2+/-1.4 ng/mgCr)无显著差异(P=0.70)。在狼疮患者中，F-2异前列腺素水平与患者报告的疾病活动(VAS)(OR=1.52，P=0.01)、疲劳(FSS，OR=1.52，P=0.03)和较低的生活质量(OR=0.73，P=0.05)独立相关，但与客观指标、炎症或疾病活动无关。总之，F-2异前列腺素的分泌与SLE患者报告的症状有关，但与炎症指标、SLEDAI或SLICC无关。氧化应激可能会导致系统性红斑狼疮的疲劳等衰弱症状。
Oxidative stress may play a role in the pathogenesis of systemic lupus erythernatosus (SLE). We examined the hypothesis that oxidative stress was associated with indices of lupus disease activity and severity of symptoms. Urinary F-2 isoprostane excretion, a validated marker of oxidative stress, was measured in 95 patients with SLE and 103 healthy controls. Outcome measures included SLEDAI and SLICC scores, the modified health assessment questionnaire, the fatigue severity scale (FSS), and visual analogue scales (VAS) for fatigue, pain and overall disease activity. F-2 isoprostane excretion was compared in patients and controls, and its relationship with clinical variables in SLE examined. F 2 isoprostane excretion did not differ significantly among patients with lupus (2.7 +/- 2.3 ng/mg Cr) and control subjects (2.2 +/- 1.4ng/mg Cr) (P = 0.70). In patients with lupus, F-2 isoprostane concentrations were independently associated with higher patient reported disease activity (VAS) (OR = 1.52, P = 0.01), fatigue (FSS, OR = 1.52, P = 0.03) and lower quality of life (OR = 0.73, P = 0.05), but not with objective markers or inflammation or disease activity. In conclusion, F-2 isoprostane excretion is associated with patient-reported symptoms in SLE but not with measures of inflammation, SLEDAI or SLICC. Oxidative stress may contribute to debilitating symptoms such as fatigue in SLE.