Comparison of inflammatory cytokine levels among type I/type II and manic/hypomanic/euthymicidepressive states of bipolar disorder
Comparison of inflammatory cytokine levels among type I/type II and manic/hypomanic/euthymicidepressive states of bipolar disorder
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DOI：
10.1016/j.jad.2014.05.009
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发表时间：
2014-09-01
影响因子：
6.6
通讯作者：
Chen, Mu-Hong
中科院分区：
文献类型：
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作者：
Bai, Ya-Mei;Su, Tung-Ping;Chen, Mu-Hong
目的：炎症细胞因子已被认为是双相情感障碍的特征或状态标志物，但结果不一致。这可能与样本量小和一些重要混杂因素控制不佳有关。方法：纳入性别/年龄匹配的双相情感障碍门诊患者和正常对照者。使用蒙哥马利·阿斯伯格抑郁评定量表和年轻躁狂评定量表对临床症状进行评定。通过酶联免疫吸附试验评估炎症细胞因子，包括可溶性白细胞介素 6 受体 (sIL-6R)、可溶性白细胞介素 2 受体 (sIL-2R)、反应蛋白 (CRP)、可溶性肿瘤坏死因子受体 1 型 (sTNF-R1)、可溶性 P-选择素受体 (5P-select:in) 和单核细胞趋化蛋白 1 (MCP-1)。 结果：总共招募了 130 名双相情感障碍患者和 130 名正常受试者。双相情感障碍患者中，双相I型障碍77例（59.2%），双相II型障碍53例（40.8%）； 75 人（57.7%）处于正常状态，14 人（10.8%）处于躁狂/轻躁狂状态，41 人（31.5%）处于抑郁状态。 130 名双相情感障碍患者的所有细胞因子水平均显着高于正常对照（所有 p < 0.0001）。通过控制年龄、性别、BMI、吸烟、病程和药物分组的多变量回归分析，II型双相情感障碍患者的sTNF-R1水平显着低于I型双相情感障碍患者（p=0.038）；抑郁状态患者的 sTNF-R1 水平显着低于躁狂/轻躁狂和情绪正常状态患者 (p=0.009)。结论：该研究支持双相情感障碍与炎症失调之间的关联，并且 sTNF-R1 可能是双相情感障碍分期的潜在生物标志物。 (C) 2014 Elsevier B.V. 保留所有权利。
Objective: Inflammatory cytokines have been suggested to be the trait or state markers of bipolar disorder, but with inconsistent results. This may be related to small sample sizes and poor control of some important confounding factors.Methods: Gender/age-matched outpatients with bipolar disorder and normal controls were enrolled. The clinical symptoms were rated using the Montgomery Asberg Depression Rating Scale and Young Mania Rating Scale. Inflammatory cytokines, including soluble interleukin-6 receptor (sIL-6R), soluble interleukin-2 receptor (sIL-2R), creactive protein (CRP), soluble tumor necrosis factor receptor type 1 (sTNF-R1), soluble P-selectin receptor (5P-select:in), and monocyte chemotactic protein-1 (MCP-1), were assessed by enzyme linked immunosorbent assays.Results: In total, 130 patients with bipolar disorder and 130 normal subjects were enrolled. Among the patients with bipolar disorder, 77(59.2%) had bipolar l disorder, 53 (40.8%) had bipolar II disorder; 75 (57.7%) were in a euthymic state, 14 (10.8%) were in a manic/hypomanic state, and 41 (31.5%) were in a depressive state. The 130 bipolar patients had significantly higher levels of all cytokines than the normal controls (all p < 0.0001). Using multivariate regression analysis with controlling of age, gender, BMI, smoking, duration of illness, and medication grouping, the patients with bipolar II disorder had significantly lower levels of sTNF-R1 than the patients with bipolar I disorder (p=0.038); the patients in a depressive state had significantly lower levels of sTNF-R1 than the patients in manic/hypomanic and euthymic states (p=0.009).Conclusion: The study supported the association of bipolar disorder with inflammatory dysregulation, and sTNF-R1 may be a potential biomarker for staging bipolar disorder. (C) 2014 Elsevier B.V. All rights reserved.