Highly Enantioselective Benzoin Condensation Reactions Involving a Bifunctional Protic Pentafluorophenyl-Substituted Triazolium Precatalyst
Highly Enantioselective Benzoin Condensation Reactions Involving a Bifunctional Protic Pentafluorophenyl-Substituted Triazolium Precatalyst
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DOI：
10.1021/jo902018j
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发表时间：
2009-12-04
影响因子：
3.6
通讯作者：
Connon, Stephen J.
中科院分区：
文献类型：
--
作者：
Baragwanath, Louise;Rose, Christopher A.;Connon, Stephen J.
通过引入氢键供体取代基来改善对映控制和酸化五氟苯基取代基来提高催化剂效率，改进了催化剂设计，得到了三唑离子预催化剂，以优异的效率和前所未有的对映选择性促进了不对称原型苯并苯甲酸的缩合。
Improved catalyst design by incorporating a hydrogen bond donating substituent to improve enantiocontrol together with an acidifying pentafluorophenyl substituent to enhance catalyst efficiency results in a triazolium ion precatalyst that promotes the asymmetric archetypal benzoin condensation with excellent efficiency and unprecedented enantioselectivity.