Preoperative Neutrophil/Lymphocyte Ratio Predicts Overall Survival and Extravesical Disease in Patients Undergoing Radical Cystectomy
Preoperative Neutrophil/Lymphocyte Ratio Predicts Overall Survival and Extravesical Disease in Patients Undergoing Radical Cystectomy
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DOI：
10.1089/end.2012.0606
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发表时间：
2013-08-01
影响因子：
2.7
通讯作者：
Hemal, Ashok K.
中科院分区：
文献类型：
--
作者：
Krane, L. Spencer;Richards, Kyle A.;Hemal, Ashok K.
目的：评估血液学参数和炎症标志物是否可以预测复发性高级别T-1或肌层浸润性膀胱癌患者根治性膀胱切除术后的膀胱外肿瘤和总生存率。本研究包括2005年4月至2011年10月期间在我院进行根治性膀胱癌手术的68例连续病例，术前血液学参数包括在内。分析.我们用单变量和多变量考克斯比例风险比评估术前特征，以帮助对总生存率进行风险分层。创建相对风险（RR）比和95%置信区间（CI）。我们还确定了与膀胱外肿瘤扩展的Logistic回归analysis.Results：中位总生存期为25个月（95%CI 13 - 61）。在多变量分析中，中性粒细胞/淋巴细胞比率
Purpose: To evaluate if hematologic parameters and inflammatory markers could predict extravesical tumor and overall survival after radical cystectomy for patients with recurrent high grade T-1 or muscle-invasive bladder cancer.Patients and Methods: A total of 68 consecutive cases of radical cystectomy performed with curative intent at our institution between April 2005 and October 2011 with preoperative hematologic parameters are included in this analysis. We evaluated preoperative characteristics with univariable and multivariate Cox proportional hazard ratios to assist in risk stratification for overall survival. Relative risk (RR) ratios and 95% confidence intervals (CI) were created. We also identified factors associated with extravesical tumor extension with logistic regression analysis.Results: Median overall survival in the total cohort was 25 months (95% CI 13-61). In multivariate analysis, neutrophil/lymphocyte ratio