UPDATE ON THE FREQUENCY OF ILE1016 MUTATION IN VOLTAGE-GATED SODIUM CHANNEL GENE OF AEDES AEGYPTI IN MEXICO
UPDATE ON THE FREQUENCY OF ILE1016 MUTATION IN VOLTAGE-GATED SODIUM CHANNEL GENE OF AEDES AEGYPTI IN MEXICO
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DOI：
10.2987/11-6149.1
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发表时间：
2011-12-01
影响因子：
1
通讯作者：
Flores, Adriana E.
中科院分区：
文献类型：
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作者：
Siller, Quetzaly;Ponce, Gustavo;Flores, Adriana E.
我们分析了2009年来自墨西哥14个地方的790只埃及伊蚊，以更新电压门控钠通道基因中Ile 1016等位基因频率的信息，该基因赋予对拟除虫菊酯和滴滴涕的抗性。Ile 1016突变存在于所有17个集合中，并且在阿卡普尔科（频率= 0.97），伊瓜拉（0.93）和圣尼古拉斯（0.90）接近固定。在帕努科、韦拉克鲁斯、科索莱阿卡克、科扎科尔科斯、坦托尤卡和蒙特雷采集的标本中，1016位点的基因型不符合哈迪-温伯格比例，这是由于在每种情况下都有过量的纯合子。这种突变在Ae.埃及伊蚊的灭绝可能是由于拟除虫菊酯杀虫剂的选择压力，特别是氯菊酯，在墨西哥，氯菊酯已用于蚊子控制计划超过10年。
We analyzed 790 Aedes aegypti from 14 localities of Mexico in 2009 to update information on the frequency of the Ile1016 allele in the voltage-gated sodium channel gene that confers resistance to pyrethroids and DDT. The Ile1016 mutation was present in all 17 collections, and was close to fixation in Acapulco (frequency = 0.97), Iguala (0.93), and San Nicolas (0.90). Genotypes at the 1016 locus were not in Hardy-Weinberg proportions in collections from Panuco, Veracruz, Cosoleacaque, Coatzacoalcos, Tantoyuca, and Monterrey due in every case to an excess of homozygotes. The high frequencies of this mutation in Ae. aegypti are probably due to selection pressure from pyrethroid insecticides, particularly permethrin, which has been used in mosquito control programs for >10 years in Mexico.