Classical swine fever virus in South-Eastern Europe-Retrospective analysis of the disease situation and molecular epidemiology
Classical swine fever virus in South-Eastern Europe-Retrospective analysis of the disease situation and molecular epidemiology
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DOI：
10.1016/j.vetmic.2010.05.035
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发表时间：
2010-12-15
影响因子：
3.3
通讯作者：
Greiser-Wilke, Irene
中科院分区：
文献类型：
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作者：
Blome, Sandra;Grotha, Inga;Greiser-Wilke, Irene
猪瘟（Classical Swine Fever，CSF）是家猪的主要疾病之一，给社会经济造成巨大损失。因此，欧洲联盟高度重视脑脊液的控制，包括为候选国和潜在候选国的协调控制行动提供财政支助。不幸的是，其中一些国家关于脑脊液情况的资料和相关数据非常有限。本研究旨在收集关于家猪种群和畜牧业的所有可用信息，以及最近加入或正在申请加入欧盟的东南欧国家家猪和野猪的CSF情况。东欧养猪业的一个特点是，大多数都是后院养猪。虽然在大多数国家进行了强制性疫苗接种，但仍有零星的CSF疫情发生。关于野猪的CSF情况仍然知之甚少。此外，对这些国家1994年至2007年爆发的97株CSF病毒分离株进行了分子流行病学研究。大多数分离株来自罗马尼亚和保加利亚。基因分型表明，几乎所有的菌株（克罗地亚和马其顿的分离株除外）属于基因型2.3。根据这些序列，以及从欧洲联盟参考实验室（EURL）数据库中获取的东欧和西欧国家暴发的其他序列，可以在亚型2.3中区分出两个集群。它们暂时被命名为2.3.1和2.3.2。(C)2010 Elsevier B.V.保留所有权利。
Classical swine fever (CSF) is among the most important diseases of domestic pigs and causes great socio-economic losses. Therefore, control of CSF is given high priority within the European Union, including financial support of concerted control actions in candidate and in potential candidate countries. Unfortunately, from some of these countries information on the CSF situation and related data is very limited. This study was undertaken to gather all available information on the domestic pig population and husbandry, and of the CSF situation in domestic pigs and wild boar in South-Eastern European countries that have recently joined or are applying to join the European Union. A characteristic feature of pig production in Eastern Europe is that most of them are in backyard holdings. Although mandatory vaccination is carried out in most of these countries, sporadic CSF outbreaks still occur. Little is still known about the CSF situation in wild boar. In addition, molecular epidemiology of 97 CSF virus isolates available from these countries, from outbreaks that occurred between 1994 and 2007, was performed. Most of the isolates were from Romania and Bulgaria. Genetic typing showed that almost all isolates (with exception of Croatian and of the Macedonian isolates) belonged to genotype 2.3. On the basis of these sequences, and additional sequences from outbreaks in Eastern and Western European countries taken from the database held at the European Union Reference Laboratory (EURL), two clusters could be distinguished within subtype 2.3. They were tentatively named 2.3.1 and 2.3.2. (C) 2010 Elsevier B.V. All rights reserved.