Hydrolase-catalyzed fast Henry reaction of nitroalkanes and aldehydes in organic media
Hydrolase-catalyzed fast Henry reaction of nitroalkanes and aldehydes in organic media
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有机介质中硝基烷烃和醛类水解酶催化的快速亨利反应
DOI：
10.1016/j.jbiotec.2009.11.022
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发表时间：
2010-02-01
影响因子：
4.1
通讯作者：
Lin, Xian-Fu
中科院分区：
文献类型：
--
作者：
Wang, Jun-Liang;Li, Xia;Lin, Xian-Fu
在D-氨基酰化酶的催化下，硝基烷烃在DMSO中与各种结构不同的醛发生快速加成反应。考察了溶剂、温度、酶浓度、底物摩尔比等因素对反应的影响。在短时间内得到了17个产品，产率中等至较高。首次报道了有机溶剂中水解酶催化的快速亨利反应。(C)2009爱思唯尔有限公司版权所有。
Nitroalkanes underwent fast additions to a variety of structurally diverse alclehydes under the catalysis of D-aminoacylase in DMSO. The influences of reaction conditions including solvents, temperature, enzyme concentration and molar ratio of substrates were systematically investigated. Seventeen products were obtained in short time with moderate to high yields. It is the first report on hydrolase-catalyzed fast Henry reaction in organic solvent. (C) 2009 Elsevier B.V. All rights reserved.