A new family of iron-dependent halogenases acts on freestanding substrates
A new family of iron-dependent halogenases acts on freestanding substrates
复制标题
DOI：
10.1038/nchembio.1625
复制
发表时间：
2014-11-01
影响因子：
14.8
通讯作者：
Liu, Xinyu
中科院分区：
文献类型：
--
作者：
Hillwig, Matthew L.;Liu, Xinyu
Regio- and stereospecific incorporation of a halogen atom to an unactivated sp(3) carbon in a freestanding molecule is a challenging transformation that is currently missing in the inventory of enzyme-mediated reactions. Here we report what is to our knowledge the first example of a nonheme iron enzyme (WelO5) in the welwitindolinone biosynthetic pathway that can monochlorinate an aliphatic carbon in 12-epi-fischerindole U and 12-epi-hapalindole C, substrates that are free from peptidyl or acyl carrier protein.
