β-lactamases of Kluyvera ascorbata, probable progenitors of some plasmid-encoded CTX-M types
β-lactamases of Kluyvera ascorbata, probable progenitors of some plasmid-encoded CTX-M types
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DOI：
10.1128/aac.46.9.3045-3049.2002
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发表时间：
2002-09-01
影响因子：
4.9
通讯作者：
Philippon, A
中科院分区：
文献类型：
--
作者：
Humeniuk, C;Arlet, G;Philippon, A
抗坏血酸克鲁维菌产生β-内酰胺酶，导致非典型的敏感模式，包括对青霉素类、头孢噻吩类和头孢呋辛的低水平耐药性，但这种耐药性可被克拉维汀逆转。获得了相应基因bla（KLUA）的10个核苷酸序列，发现它们具有微小的变异（96%至100%）。另外，发现bla（KLUA）与一些质粒编码的CTX-M型β-内酰胺酶相似（95 - 100%）。最后，发现bla（KLUA）在质粒上的移动可能由遗传移动的元件如ISEcp 1介导。
Kluyvera ascorbata produces a beta-lactamase that results in an atypical susceptibility pattern, including low-level resistance to penicillins, cephalothin, and cefuroxime, but this resistance is reversed by clavulanate. Ten nucleotide sequences of the corresponding gene, bla(KLUA), were obtained and were found to have minor variations (96 to 100%). Otherwise, bla(KLUA) was found to be similar (95 to 100%) to some plasmid-encoded CTX-M-type beta-lactamases. Finally, mobilization of bla(KLUA), on a plasmid was found to be mediated probably by a genetic mobile element like ISEcp1.