Anti-hyperglycemic and anti-hyperlipidemic effects of guava leaf extract.
Anti-hyperglycemic and anti-hyperlipidemic effects of guava leaf extract.
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DOI：
10.1186/1743-7075-7-9
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发表时间：
2010-02-02
影响因子：
4.5
通讯作者：
Miyazaki K
中科院分区：
文献类型：
--
作者：
Deguchi Y;Miyazaki K
番石榴番石榴（番石榴）由于其药理活性，在世界各地的亚热带地区不仅被用作食物，而且还被用作民间药物。特别是，番石榴叶提取物传统上用于东亚和其他国家的糖尿病治疗。此外，在一些动物模型中已经报道了提取物的抗高血糖活性。然而，关于提取物在人体临床试验中的治疗活性及其潜在的治疗机制和安全性知之甚少。在日本，含有番石榴叶水提取物的番石榴叶茶（Bansoureicha®，Yakult Honsha，Tokyo，Japan）已被批准为特定健康用途食品之一，现已上市。本文综述了番石榴叶水提取物的活性成分及其对α-葡萄糖苷酶的体外抑制作用，番石榴叶水提取物和番石榴叶茶的安全性，在小鼠模型和几项临床试验中降低餐后血糖升高，改善高血糖、高胰岛素血症、低脂联素血症、高甘油三酯血症和高胆固醇血症。这表明，餐后血糖升高的慢性抑制在预防2型糖尿病中是重要的，并且番石榴叶茶被认为是用于慢性治疗的营养疗法。
Psidium guajava Linn. (guava) is used not only as food but also as folk medicine in subtropical areas around the world because of its pharmacologic activities. In particular, the leaf extract of guava has traditionally been used for the treatment of diabetes in East Asia and other countries. Moreover, the anti-hyperglycemic activity of the extract has been reported in some animal models. However, little is known regarding the therapeutic activity of the extract in human clinical trials as well as its underlying therapeutic mechanisms and safety. In Japan, Guava Leaf Tea (Bansoureicha®, Yakult Honsha, Tokyo, Japan) containing the aqueous leaf extract from guava has been approved as one of the Foods for Specified Health Uses and is now commercially available. This review describes the active component of the aqueous guava leaf extract and its inhibition of alpha-glucosidase enzymes in vitro, safety of the extract and Guava Leaf Tea, reduction of postprandial blood glucose elevation, and improvement of hyperglycemia, hyperinsulinemia, hypoadiponectinemia, hypertriglycemia and hypercholesterolemia in murine models and several clinical trials. It is suggested that the chronic suppression of postprandial blood glucose elevation is important in preventing type 2 diabetes mellitus, and that Guava Leaf Tea is considered useful as an alimentotherapy for chronic treatment.
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影响因子：
168.9
作者：
Kawamori, Ryuzo;Tajima, Naoko;Koku, Kohei
通讯作者：
Koku, Kohei
影响因子：
7.7
作者：
LEE, SM;BRESSLER, R
通讯作者：
BRESSLER, R
影响因子：
5.8
作者：
Cavalot, F;Petrelli, A;Trovati, M
通讯作者：
Trovati, M
影响因子：
120.7
作者：
Chiasson, JL;Josse, RG;Laakso, M
通讯作者：
Laakso, M
DOI：
10.2165/00129784-200404050-00002
发表时间：
2004-01-01
期刊：
American journal of cardiovascular drugs : drugs, devices, and other interventions
影响因子：
--
作者：
Bailey, David G;Dresser, George K
通讯作者：
Dresser, George K