RETROSPECTIVE AND PROSPECTIVE EPIDEMIOLOGICAL-STUDIES OF 1500 KARYOTYPED SPONTANEOUS HUMAN ABORTIONS
RETROSPECTIVE AND PROSPECTIVE EPIDEMIOLOGICAL-STUDIES OF 1500 KARYOTYPED SPONTANEOUS HUMAN ABORTIONS
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DOI：
10.1002/tera.1420120103
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发表时间：
1975-01-01
期刊：
影响因子：
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通讯作者：
LAZAR, P
中科院分区：
文献类型：
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作者：
BOUE, J;BOUE, A;LAZAR, P
回顾性和前瞻性流行病学研究对1966 - 1972年收集的1500例堕胎进行了研究。没有观察到长期或季节性变化。通过分析不同类型染色体异常的相对频率，估计每2个受孕中就有1个存在染色体异常。母亲年龄的影响仅见于常染色体三体组，主要是D和G三体。未发现口服避孕药的影响。在促排卵治疗后和父亲职业暴露于辐射后，染色体异常的频率增加。生育率和流产后新生儿先天畸形的发生率没有变化。反复流产的发生率主要受流产前夫妇生育史的影响。
Epidemiologic studies, retrospective and prospective, were done on 1500 abortions collected from 1966‐1972. No secular or seasonal variations were observed. From the analysis of the relative frequencies of the different types of chromosome anomalies it is estimated that 1 out of every 2 conceptions has a chromosome anomaly. Maternal‐age influence was found only for the autosomal trisomy group, mainly D and G trisomies. No effect of oral contraceptives was discovered. An increased frequency of chromosome anomalies occurred after ovulation‐inducing therapy and after occupational exposure of the father to irradiation. No variations in the fertility rate and in the frequency of congenital malformations in births following abortions was noted. The incidence of recurring abortion was mainly influenced by the reproductive history of the couple before the karyotyped abortion.