Expression of annexin‐1 in multiple sclerosis plaques
Expression of annexin‐1 in multiple sclerosis plaques
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DOI：
10.1046/j.1365-2990.2002.00396.x
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发表时间：
2002-08
影响因子：
5
通讯作者：
S. Probst‐Cousin;D. Kowolik;K. Kuchelmeister;C. Kayser;B. Neundörfer;D. Heuss
中科院分区：
文献类型：
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作者：
S. Probst‐Cousin;D. Kowolik;K. Kuchelmeister;C. Kayser;B. Neundörfer;D. Heuss
这项研究描述了多发性硬化症（MS）患者中枢神经系统中膜联蛋白-1阳性细胞的分布和身份。糖皮质激素诱导的抗炎特性归因于膜联蛋白-1，它是钙结合蛋白家族的一员，统称为膜联蛋白。我们已经发现膜联蛋白-1与活动性MS病变在空间上相关，并证明了膜联蛋白-1在MS斑块中的阶段依赖性表达。MS病变中所有最重要的致病相关细胞均显示出强烈的膜联蛋白-1反应性。相关性分析和双重染色程序均表明，膜联蛋白-1在巨噬细胞和血管周围淋巴细胞中表达，其中显示细胞质反应性，而在活化的Gemistocytic星形胶质细胞中，它也集中在质膜附近。虽然膜联蛋白-1在这种情况下的确切作用仍有待确定，但可能有助于抗炎过程。
This study describes the distribution and identity of annexin‐1 positive cells in the central nervous system in patients with multiple sclerosis (MS). Glucocorticoid‐inducible, anti‐inflammatory properties have been ascribed to annexin‐1, a member of a family of calcium‐binding proteins that are referred to collectively as annexins. We have found annexin‐1 to be spatially associated with active MS lesions and demonstrated a stage‐dependent expression of annexin‐1 in MS plaques. All of the most important pathogenetically involved cells of MS lesions showed a strong annexin‐1 reactivity. Both correlation analysis and double staining procedures suggested annexin‐1 expression in macrophages and perivascular lymphocytes, where a cytoplasmic reactivity was displayed, whereas in activated, gemistocytic astrocytes it was also concentrated close to the plasma membrane. Although the exact roles of annexin‐1 in this setting are still to be determined, a possible contribution to anti‐inflammatory processes might be suggested.