Parkinson's disease and diplopia
Parkinson's disease and diplopia
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DOI：
10.1080/01658100600742838
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发表时间：
2006-01-01
影响因子：
0.8
通讯作者：
Lepore, FE
中科院分区：
文献类型：
--
作者：
Lepore, FE
目的：描述帕金森病（PD）患者的眼共轭异常。研究方法：对44名连续的具有复视的PD患者（和9名没有复视的PD对照）进行了眼共轭异常检查，包括会聚不足（CI）。结果如下：42例PD患者有CI伴或不伴复视（2例无法测试），15/44例PD患者还具有不同病因的远距离复视（上斜视-9例，外斜视-4例，可变水平斜视-1例，内斜视-1例）。所有（9/9）对照组患者均有CI。这些年龄相似、无复视、PD持续时间较短（P = 0.05）的患者CI的会聚融合幅度显著大于（p < 0.0001）有复视的PD患者。结论：先前的研究低估了有视力主诉的PD患者的CI频率。在该系列中，100%的复视患者患有CI。比较有和没有复视的PD患者表明，会聚融合幅度随着疾病持续时间的增加而降低。CI是PD的常见伴随物，PD是复视的最常见原因，并且可能反映神经病理学。
Objective : To describe the spectrum of ocular dysconjugacy in Parkinson's disease (PD). Methods : Forty-four consecutive PD patients with diplopia (and 9 PD controls without diplopia) were examined for ocular dysconjugacy, including convergence insufficiency (CI). Results : Forty-two PD patients had CI with or without diplopia (2 could not be tested), and 15/44 PD patients also had distance diplopia (hypertropia-9, exotropia-4, variable horizontal heterotropia-1, esotropia-1) of diverse etiologies. All (9/9) control patients had CI. These patients of similar age without diplopia and with shorter duration of PD (P = 0.05) had CI with significantly greater (p < 0.0001) convergence fusional amplitudes than PD patients with diplopia. Conclusions: Prior studies underestimate the frequency of CI in PD patients with visual complaints. In this series 100% of tested patients with diplopia had CI. Comparison of PD patients with and without diplopia demonstrates that convergence fusional amplitudes decrease as disease duration increases. CI is a common accompaniment of PD, the most frequent cause of diplopia, and may reflect extranigral pathology.