CAN AVERSIVE PROPERTIES OF (PERIPHERALLY-INJECTED) VASOPRESSIN ACCOUNT FOR ITS PUTATIVE ROLE IN MEMORY
CAN AVERSIVE PROPERTIES OF (PERIPHERALLY-INJECTED) VASOPRESSIN ACCOUNT FOR ITS PUTATIVE ROLE IN MEMORY
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DOI：
10.1016/0166-4328(83)90024-4
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发表时间：
1983-01-01
影响因子：
2.7
通讯作者：
BLOOM, FE
中科院分区：
文献类型：
--
作者：
ETTENBERG, A;VANDERKOOY, D;BLOOM, FE
大鼠注射精氨酸加压素（AVP）后立即暴露于一个新的开放领域的环境中发现一个水管快于盐水注射大鼠，当水剥夺48小时后。在实验组中，这种效应不是由条件反射或药理学诱导的多动症引起的。虽然这些结果与AVP在记忆机制中的作用一致，但已知的致病剂LiCl减少了寻找水管的潜伏期，与AVP相同。AVP在条件味觉和位置厌恶研究中是一种有效的非条件刺激。AVP也产生了剂量依赖性的自发活动中断。显然，外周AVP给药具有令人厌恶的后果。去甘氨酰胺精氨酸加压素（一种AVP类似物，具有弱的加压素-激动剂特性）没有产生可观察到的厌恶效应，也没有改善食欲找水任务中的测试性能。外周施用AVP的明显的记忆增强特性，至少在食欲测试范例中，可能取决于其厌恶和因此引起的动作。
Rats injected with arginine vasopressin (AVP) immediately after exposure to a novel open-field environment found a water tube faster than saline injected rats, when water-deprived 48 h later. This effect did not result from a conditioned or pharmacologically-induced hyperactivity in the experimental group. Although these results are consistent with a role for AVP in memory mehcanisms, LiCl, a known illness-producing agent, produced a reduction in latency to find the water tube identical to that of AVP. AVP acted as an effective unconditioned stimulus in conditioned taste and place aversion studies. AVP also produced a dose-dependent disruption of spontaneous locomotor activity. Apparently, peripheral AVP administration has aversive consequences. Desglycinamide arginine vasopressin (an AVP analog with weak pressor-agonist properties) produced no observable aversive effects and did not improve test performance in the appetitive water-finding task. The apparent memory-enhancing properties of peripherally administered AVP, at least in appetitive test paradigms, may depend on its aversive and consequently arousing actions.