Synthesis of polycyclic spiroindolines via the cascade reaction of 3-(2-isocyanoethyl)indoles
Synthesis of polycyclic spiroindolines via the cascade reaction of 3-(2-isocyanoethyl)indoles
复制标题
3-(2-异氰乙基)吲哚级联反应合成多环螺吲哚啉
DOI：
10.1039/d1cc04576h
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发表时间：
2021-09-30
影响因子：
4.9
通讯作者：
Li, Wei-Dong Z.
中科院分区：
文献类型：
--
作者：
Li, Haizhen;Wu, Jinyu;Li, Wei-Dong Z.
报道了钇（Ⅲ）催化的2，2 '-二酯氮杂环丙烷与3-（2-异氰乙基）吲哚的开环反应及随后的Friedel-Crafts/Mannich/N-乙酰基化反应的串联反应。在温和的反应条件下，一步合成了一系列含四氢-β-咔啉的多环螺吲哚啉，产率为56-92%。并提出了可能的催化机理。
Tandem reactions of the yttrium(iii) catalyzed ring-opening reaction of 2,2 '-diester aziridines with 3-(2-isocyanoethyl)indoles and the subsequent Friedel-Crafts/Mannich/desulfonylation were reported. A series of polycyclic spiroindolines containing tetrahydro-beta-carbolines were obtained in moderate to excellent yields (56-92%) in one step under mild reaction conditions. A possible catalytic mechanism was also proposed.