Pressure-based simultaneous CFR and FFR measurements: understanding the physiology of a stenosed vessel
Pressure-based simultaneous CFR and FFR measurements: understanding the physiology of a stenosed vessel
复制标题
基于压力的同步 CFR 和 FFR 测量：了解狭窄血管的生理学
DOI：
10.1016/s0010-4825(01)00010-5
复制
发表时间：
2001
影响因子：
7.7
通讯作者：
M. Rosenfeld
中科院分区：
文献类型：
--
作者：
E. Shalman;C. Barak;E. Dgany;H. Noskowitcz;S. Einav;M. Rosenfeld
动脉狭窄被认为是最严重的心血管疾病之一。血管造影术对动脉狭窄的估计提供了关于闭塞的严重程度和通过闭塞的血液流动的有限信息。血流动力学对血流和压力行为的评估具有重要的临床意义。基于血流动力学的参数，如基于压力的心肌血流储备分数(FFR)和基于血流的冠状动脉血流储备(CFR)被引入，为动脉疾病的治疗提供了更好的工具。我们开发了一种同时测量压力衍生CFR和FFR的新方法。压力衍生血流动力学参数的优势是非常显著的，其在临床环境中相对直接的应用也是可靠的。该方法已经通过动脉狭窄的计算流体动力学(CFD)模型和体外台架实验进行了验证。
Arterial stenosis is known to be one of the most serious cardiovascular diseases. Angiographical estimation of arterial stenosis provides limited information on the severity of the occlusion and the flow of blood through it. Hemodynamical assessment of the flow and pressure behaviour, is known to be clinically important. Hemodynamically based parameters, such as pressure based myocardial fractional flow reserve (FFR) and the flow based coronary flow reserved (CFR) were introduced to provide a much better tool for treating arterial diseases. We have developed a new method for simultaneous measurement of pressure-derived CFR and FFR. The advantage of pressure derived hemodynamic parameters is very substantial, and its relatively straightforward application in clinical setting is solid. The method has been validated by means of a computational fluid dynamics (CFD) model of the arterial stenosis and in vitro bench studies.