Acute central nervous system changes due to intoxication by Manzidan (a combined dithiocarbamate of Maneb and Zineb).
Acute central nervous system changes due to intoxication by Manzidan (a combined dithiocarbamate of Maneb and Zineb).
复制标题
Manzidan（代森锰和代森锌的组合二硫代氨基甲酸盐）中毒导致中枢神经系统发生急性变化。
DOI：
10.1007/978-3-642-69083-9_43
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
P. Tiberin
中科院分区：
文献类型：
--
作者：
R. Israeli;M. Sculsky;P. Tiberin
一名42岁的男子在黄瓜种植园喷洒Manzidan（Maneb和Zineb的二硫代氨基甲酸盐），一周两次。第一次用药后出现行为变化，第二次用药后出现意识丧失、惊厥和右侧轻偏瘫，EEG显示弥漫性慢节律。几天后，行为学和CNS神经病学均自发消失。患者的既往病史、症状的突然出现和自发消失以及剂量-反应关系强烈表明Maneb和Zineb是疾病的原因。
A 42-year old man sprayed Manzidan (a combined dithiocarbamate of Maneb and Zineb) on a cucumber plantation, twice during a week. Behavioural changes appeared after the first application, and loss of consciousness, convulsions and right hemiparesis after the second application with diffuse slow rhythm in the EEG. Both the behavioural and CNS symptomatology disappeared spontaneously after a few days. The previous history of the patient, the sudden appearance and spontaneous disappearance of the symptoms and a dose-response relationship strongly suggest that Maneb and Zineb were the cause of the illness.