A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering
A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering
复制标题
实验室小角X射线散射诊断乳腺癌的初步研究
DOI：
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发表时间：
2005
影响因子：
3.5
通讯作者：
Ian O. Ellis
中科院分区：
文献类型：
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作者：
A. Round;S. Wilkinson;C. Hall;K. Rogers;Otto Glatter;T. Wess;Ian O. Ellis
采用小角X射线散射法对双侧乳癌切除手术中采集的乳腺组织和正常乳腺组织进行检查。以前的工作已经表明，可以使用来自同步辐射源的小角x射线散射(SAXS)来进行乳腺组织疾病的诊断。如果这项技术能够使用传统的X射线源来工作，那么它将对医疗服务更有用。使用基于实验室的‘SAXSess’系统，从正常组织样本和肿瘤组织样本中观察到x射线散射分布的一致和可靠的差异。虽然来自少量样品，但获得了100%的灵敏度。这一结果鼓励我们将SAXS作为一种基于实验室的诊断技术来实施。
Breast tissue collected from tumour samples and normal tissue from bi-lateral mastectomy procedures were examined using small angle x-ray scattering. Previous work has indicated that breast tissue disease diagnosis could be performed using small angle x-ray scattering (SAXS) from a synchrotron radiation source. The technique would be more useful to health services if it could be made to work using a conventional x-ray source. Consistent and reliable differences in x-ray scatter distributions were observed between samples from normal and tumour tissue samples using the laboratory based ‘SAXSess’ system. Albeit from a small number of samples, a sensitivity of 100% was obtained. This result encourages us to pursue the implementation of SAXS as a laboratory based diagnosis technique.