Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ob mice
Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ob mice
复制标题
DOI：
10.1016/j.neulet.2007.12.051
复制
发表时间：
2008-03-12
影响因子：
2.5
通讯作者：
Thio, Liu Lin
中科院分区：
文献类型：
--
作者：
Erbayat-Altay, Ebru;Yamada, Kelvin A.;Thio, Liu Lin
瘦素调节多个离子通道，使其对大脑兴奋性的净影响难以预测。确定瘦素对大脑兴奋性的净效应的一种方法是检查慢性瘦素缺乏期间的大脑兴奋性。我们使用连续视频脑电图（EEG）记录比较了瘦素缺陷型ob/ob和野生型小鼠对戊四氮（PTZ）诱导癫痫发作的易感性。我们发现，ob/ob小鼠更容易死亡，更容易受到全身性阵挛性和阵挛性强直性癫痫发作比野生型小鼠在次最大PTZ剂量。这些发现表明，体内慢性瘦素缺乏增加癫痫发作的易感性。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
Leptin modulates multiple ion channels making its net effect on brain excitability difficult to predict. One method of determining leptin's net effect on brain excitability is to examine brain excitability during chronic leptin deficiency. We compared the susceptibility of leptin deficient ob/ob and wild type mice to pentylenetetrazol (PTZ) induced seizures using continuous video electroencephalogram (EEG) recordings. We found that ob/ob mice were more likely to die and were more susceptible to generalized clonic and clonic-tonic seizures than wild type mice at submaximal PTZ doses. These findings suggest that chronic leptin deficiency in vivo increases seizure susceptibility. (C) 2007 Elsevier Ireland Ltd. All rights reserved.