Tenofovir-associated Fanconi syndrome and nephrotic syndrome in a patient with chronic hepatitis B monoinfection
Tenofovir-associated Fanconi syndrome and nephrotic syndrome in a patient with chronic hepatitis B monoinfection
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DOI：
10.1002/hep.27730
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发表时间：
2015-10-01
期刊：
影响因子：
13.5
通讯作者：
Song, Myeong Jun
中科院分区：
文献类型：
--
作者：
Hwang, Hyeon Seok;Park, Cheol Whee;Song, Myeong Jun
富马酸替诺福韦二吡呋酯 (TDF) 被广泛用作治疗慢性乙型肝炎 (CHB) 感染的有效一线疗法。虽然 TDF 表现出成功的病毒抑制作用，但它与肾近端肾小管 (PT) 功能障碍的发生有关，从而导致范可尼综合征。然而，在CHB单一感染患者中范可尼综合征的报道很少，也没有TDF相关肾病综合征的报道。在这里，我们报告了一例慢性乙型肝炎患者暴露于 TDF 后合并范可尼和肾病综合征的病例。 （肝病学 2015；62：1318-1320）
Tenofovir disoproxil fumarate (TDF) is widely used as an effective first-line therapy for chronic hepatitis B (CHB) infection. While TDF demonstrates successful viral suppression, it has been linked to the development of renal proximal tubular (PT) dysfunction, leading to Fanconi syndrome. However, Fanconi syndrome has been rarely reported in CHB-monoinfected patients, and there were no reports of TDF-associated nephrotic syndrome. Here, we report a case of combined Fanconi and nephrotic syndrome in CHB patients after TDF exposure. (Hepatology 2015;62:1318-1320)