Chemokine blockade for lupus model mice
Chemokine blockade for lupus model mice
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DOI：
10.2741/2894
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发表时间：
2008-01-01
影响因子：
3.1
通讯作者：
Hasegawa, Hitoshi
中科院分区：
文献类型：
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作者：
Hasegawa, Hitoshi
在过去的十年中，越来越多的证据表明，在人类和小鼠模型中，趋化因子和趋化因子受体在自身免疫性疾病的发病机制中起着至关重要的作用。局部分泌的趋化因子及其受体是白细胞向组织募集的重要介质，并有助于自身免疫性疾病的发生和发展。因此，阻断趋化因子和趋化因子受体相互作用已成为一种新的治疗策略。MRL/MpJ-lpr/lpr（MRL/lpr）和（NZB X NZW）F1小鼠是两种自发性自身免疫性疾病的小鼠，它们与人类系统性红斑狼疮（SLE）相似，是研究SLE发病机制的理想模型。此外，在人类和狼疮模型小鼠，特别是MRL/lpr小鼠中，炎症器官中趋化因子和趋化因子受体的表达模式相似。因此，从狼疮模型小鼠的实验中获得的发现可能适用于治疗人类的这些自身免疫性疾病。本文就趋化因子及其受体在自身免疫性疾病发病机制中的作用以及阻断趋化因子治疗狼疮模型小鼠的研究进展作一综述。
Over the past decade, accumulating evidence has indicated a crucial role for chemokines and chemokine receptors in the pathogenesis of autoimmune diseases in both human and mouse models. Locally secreted chemokines and their receptors are important mediators of leukocyte recruitment to the tissues, and contribute to the initiation and progression of autoimmune diseases. Thus, blockade of chemokine and chemokine receptor interactions has emerged as a novel therapeutic strategy. MRL/MpJ-lpr/lpr (MRL/lpr) and (NZB X NZW) F1 mice, the two strains of mice that develop spontaneous autoimmune disease closely resembling human systemic lupus erythematosus (SLE), are considered to be excellent models for investigating the pathogenesis of the human disease. In addition, similar expression patterns of chemokines and chemokine receptors in inflamed organs are shown in humans and lupus model mice, especially MRL/lpr mice. Therefore, findings obtained from experiments with lupus model mice may be applicable to the treatment of these autoimmune diseases in humans. In this article, we review the role of chemokines and chemokine receptors involved in the pathogenesis of autoimmune diseases and the therapeutic approach of chemokine blockade in lupus model mice.