Adverse effects of antiretroviral therapy
Adverse effects of antiretroviral therapy
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DOI：
10.1016/s0140-6736(00)02854-3
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发表时间：
2000-10-21
期刊：
影响因子：
168.9
通讯作者：
Cooper, DA
中科院分区：
文献类型：
--
作者：
Carr, A;Cooper, DA
抗逆转录病毒毒性是HIV感染患者管理中日益重要的问题。随着机会性并发症的持续大幅下降，艾滋病毒感染成为一种更慢性的疾病，因此更多的药物被用于更多的患者，持续更长的时间。本文综述了15种已获许可的抗逆转录病毒药物的主要毒性，包括线粒体毒性、超敏反应和脂肪代谢障碍，以及更多药物特异性不良反应和特殊临床环境的发病机制、临床特征和管理。
Antiretroviral toxicity is an increasingly important issue in the management of HIV infected patients. With the sustained major declines in opportunistic complications, HIV infection is a more chronic disease, and so more drugs are being used in more patients for longer periods. This review focuses on the pathogenesis, clinical features, and management of the principal toxicities of the 15 licensed antiretroviral drugs, including mitochondrial toxicity, hypersensitivity, and lipodystrophy, as well as more drug-specific adverse effects and special clinical settings.