Beta-amyloid, blood vessels, and brain function.
Beta-amyloid, blood vessels, and brain function.
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DOI：
10.1161/strokeaha.108.536839
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发表时间：
2009-07
期刊：
影响因子：
8.3
通讯作者：
Greenberg SM
中科院分区：
文献类型：
--
作者：
Smith EE;Greenberg SM
Cerebrovascular disease and Alzheimer’s disease are common diseases of aging and frequently co-exist in the same brain. Accumulating evidence suggests that the presence of brain infarction, including silent infarction, influences the course of Alzheimer’s disease. Conversely, there is evidence that beta-amyloid can impair blood vessel function. Vascular beta-amyloid deposition, also known as cerebral amyloid angiopathy, is associated with vascular dysfunction in animal and human studies. Alzheimer’s disease is associated with morphological changes in capillary networks, and soluble beta-amyloid produces abnormal vascular responses to physiologic and pharmacologic stimuli. In this review we discuss current evidence linking beta-amyloid metabolism with vascular function and morphological changes in animals and humans.
