THE MICROGLIAL CYTOSKELETON - VIMENTIN IS LOCALIZED WITHIN ACTIVATED CELLS INSITU
THE MICROGLIAL CYTOSKELETON - VIMENTIN IS LOCALIZED WITHIN ACTIVATED CELLS INSITU
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DOI：
10.1007/bf01189811
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发表时间：
1988-08-01
期刊：
影响因子：
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通讯作者：
KREUTZBERG, GW
中科院分区：
文献类型：
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作者：
GRAEBER, MB;STREIT, WJ;KREUTZBERG, GW
与星形胶质细胞和少突胶质细胞不同，小胶质细胞具有极强的可塑性，使其成为中枢神经系统胶质细胞中的变色龙。这种小胶质细胞形状的巨大变变性表明存在一种复杂的细胞骨架，这是通过应用一种新的超微结构方法来证明的。电镜免疫细胞化学显示，大鼠面神经截轴刺激反应性小胶质细胞的中间丝区存在波形蛋白。这表明vimentin的表达可能是小胶质细胞（包括脑巨噬细胞）激活状态的标志。
Unlike astrocytes and oligodendrocytes, microglia are extremely plastic making them the chameleon among the glial cells in the CNS. This great mutability of the microglial cell shape suggests the presence of an elaborate cytoskeleton which is demonstrated here by applying a new ultrastructural method. Electron microscopic immunocytochemistry shows the presence of vimentin at intermediate filament sites in reactive microglia stimulated by rat facial nerve axotomy. It is suggested that vimentin-expression may serve as a marker for activated states of microglia, including brain macrophages.