Cross-Modality Sharpening of Visual Cortical Processing through Layer-1-Mediated Inhibition and Disinhibition.
Cross-Modality Sharpening of Visual Cortical Processing through Layer-1-Mediated Inhibition and Disinhibition.
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DOI：
10.1016/j.neuron.2016.01.027
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发表时间：
2016-03-02
期刊：
影响因子：
16.2
通讯作者：
Tao HW
中科院分区：
文献类型：
--
作者：
Ibrahim LA;Mesik L;Ji XY;Fang Q;Li HF;Li YT;Zingg B;Zhang LI;Tao HW
感官知觉中的跨通道交互作用有利于动物的生存。皮质感觉处理如何跨模式调节以及底层神经回路是什么仍然知之甚少。在小鼠初级视皮层（V1），我们发现，在初级听觉皮层（A1）到V1的投射的声音或光遗传激活的存在下，（L）2/3层而不是L4兴奋性神经元的方向选择性被锐化。这种效应表现为平均视觉反应降低，但在首选方向的反应增加。它在较低的视觉对比度下更明显，并通过抑制L1活动而减弱。L1神经元强烈支配的A1-V1轴突和兴奋的声音，而视觉反应的L2/3血管活性肠肽（VIP）神经元的声音抑制，都优先在细胞的首选方向。这些结果表明，跨通道调制主要通过L1神经元和L2/3VIP细胞介导的抑制和去抑制回路实现。
Cross-modality interaction in sensory perception is advantageous for animals’ survival. How cortical sensory processing is cross-modally modulated and what are the underlying neural circuits remain poorly understood. In mouse primary visual cortex (V1), we discovered that orientation selectivity of layer (L)2/3 but not L4 excitatory neurons was sharpened in the presence of sound or optogenetic activation of projections from primary auditory cortex (A1) to V1. The effect was manifested by decreased average visual responses yet increased responses at the preferred orientation. It was more pronounced at lower visual contrast, and was diminished by suppressing L1 activity. L1 neurons were strongly innervated by A1-V1 axons and excited by sound, while visual responses of L2/3 vasoactive intestinal peptide (VIP) neurons were suppressed by sound, both preferentially at the cell's preferred orientation. These results suggest that the cross-modality modulation is achieved primarily through L1 neuron and L2/3 VIP-cell mediated inhibitory and disinhibitory circuits.