Biomarkers in Alcohol Misuse: Their Role in the Prevention and Detection of Thiamine Deficiency
Biomarkers in Alcohol Misuse: Their Role in the Prevention and Detection of Thiamine Deficiency
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DOI：
10.1093/alcalc/agn117
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发表时间：
2009-03-01
影响因子：
2.8
通讯作者：
Ceccanti, Mauro
中科院分区：
文献类型：
--
作者：
Mancinelli, Rosanna;Ceccanti, Mauro
在西方国家，酒精滥用是硫胺素（维生素B1）缺乏症（TD）和随之而来的神经损伤的最常见原因。研究表明，30%至80%的酗酒者缺乏硫胺素，这使他们有患Wernicke-Korsakoff（WK）综合征的风险。酒精和TD在导致脑损伤中的相对作用仍然存在争议，重要的是要确定每个因素所起的作用。动物研究支持酒精暴露和TD的叠加效应，并表明酒精和TD在人类酒精相关脑损伤中的相互作用。因此，酒精相关TD的早期诊断是有效干预和治疗的一个重要方面。酒精生物标志物提供了一种直接和间接的方法来估计酒精的摄入量，摄入的持续时间以及长期饮酒对身体功能的有害影响。当考虑酒精相关TD的诊断时，适当使用这些标志物非常有帮助。
In Western countries alcohol misuse is the most frequent cause of thiamine (vitamin B1) deficiency (TD) and consequent neuro-impairment. Studies have demonstrated that between 30 and 80% of alcoholics are thiamine deficient, and this puts them at risk of developing the Wernicke-Korsakoff (WK) syndrome. The relative roles of alcohol and TD in causing brain damage remain controversial and it is important to try to determine the role played by each factor. Animal studies support an additive effect of alcohol exposure and TD, and indicate the potential for interaction between alcohol and TD in human alcohol-related brain damage. Early diagnosis of alcohol-related TD is therefore an important aspect of effective intervention and treatment. Alcohol biomarkers provide a direct and indirect way of estimating the amount of alcohol being consumed, the duration of ingestion and the harmful effects that long-term alcohol use has on body functions. Appropriate use of these markers is very helpful when considering a diagnosis of alcohol-related TD.