Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study.
Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study.
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精神分裂症的左颞叶异常和思维障碍。
DOI：
10.1056/nejm199208273270905
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Coleman,M
中科院分区：
文献类型：
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作者：
Shenton,ME;Kikinis,R;Jolesz,FA;Pollak,SD;LeMay,M;Wible,CG;Hokama,H;Martin,J;Metcalf,D;Coleman,M
背景尸检、CT和磁共振成像（MRI）研究的数据表明，精神分裂症患者可能存在左颞叶解剖异常，但尚不清楚这些异常是否与精神分裂症的思维障碍特征有关。（不知道诊断）体积测量和三维重建的颞叶结构在体内15右-结果慢性精神分裂症患者左前额叶-杏仁核灰质体积较对照组明显减少（19%[95%置信区间，3%至36%]），左侧海马旁回（13%[95%置信区间，3%至23%]，右侧为8%）和左侧上级颞回（15%[95%置信区间，5%至25%]）。13例患者的左后上级颞回体积与思维障碍指数评分相关（r =-0.81，P = 0.001）。这些区域性体积减少均不伴有整个大脑或颞叶体积的减少。在控制区域（上级额回）的灰质体积基本上是相同的，在患者和controls.ConclusionsSchizophrenia涉及本地化的左颞叶的灰质减少。思维障碍的程度与左后上级颞回体积缩小的大小有关。（N Engl J Med 1992;327：604-12.）
BackgroundData from postmortem, CT, and magnetic resonance imaging (MRI) studies indicate that patients with schizophrenia may have anatomical abnormalities of the left temporal lobe, but it is unclear whether these abnormalities are related to the thought disorder characteristic of schizophrenia.MethodsWe used new MRI neuroimaging techniques to derive (without knowledge of the diagnosis) volume measurements and three-dimensional reconstructions of temporal-lobe structures in vivo in 15 right-handed men with chronic schizophrenia and 15 matched controls.ResultsAs compared with the controls, the patients had significant reductions in the volume of gray matter in the left anterior hippocampus—amygdala (by 19 percent [95 percent confidence interval, 3 to 36 percent]), the left parahippocampal gyrus (by 13 percent [95 percent confidence interval, 3 to 23 percent], vs. 8 percent on the right), and the left superior temporal gyrus (by 15 percent [95 percent confidence interval, 5 to 25 percent]). The volume of the left posterior superior temporal gyrus correlated with the score on the thought-disorder index in the 13 patients evaluated (r = -0.81, P = 0.001). None of these regional volume decreases were accompanied by a decrease in the volume of the overall brain or temporal lobe. The volume of gray matter in a control region (the superior frontal gyrus) was essentially the same in the patients and controls.ConclusionsSchizophrenia involves localized reductions in the gray matter of the left temporal lobe. The degree of thought disorder is related to the size of the reduction in volume of the left posterior superior temporal gyrus. (N Engl J Med 1992;327:604–12.)