The emerging role of ferroptosis in intestinal disease.
The emerging role of ferroptosis in intestinal disease.
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DOI：
10.1038/s41419-021-03559-1
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发表时间：
2021-03-17
影响因子：
9
通讯作者：
Zhang S
中科院分区：
文献类型：
--
作者：
Xu S;He Y;Lin L;Chen P;Chen M;Zhang S
铁下垂是一种新发现的调节性细胞死亡(RCD)类型，其特征是铁依赖的脂质过氧化堆积。它在形态、生化和遗传水平上明显不同于其他RCDS。最近的报道表明，铁性下垂与多种疾病有关，包括神经系统疾病、肾脏损伤、肝脏疾病和癌症。铁性上皮细胞死亡也与肠道上皮功能障碍有关，这导致了几种肠道疾病。对铁性下垂的研究可能会对肠道疾病的发病机制有新的认识，有利于临床治疗。在这篇综述中，我们概述了铁下垂及其潜在的机制，然后描述了它在肠道疾病中的新角色，包括肠缺血/再灌注(I/R)损伤、炎症性肠病(IBD)和结直肠癌(CRC)。
Ferroptosis is a newly recognised type of regulated cell death (RCD) characterised by iron-dependent accumulation of lipid peroxidation. It is significantly distinct from other RCDs at the morphological, biochemical, and genetic levels. Recent reports have implicated ferroptosis in multiple diseases, including neurological disorders, kidney injury, liver diseases, and cancer. Ferroptotic cell death has also been associated with dysfunction of the intestinal epithelium, which contributes to several intestinal diseases. Research on ferroptosis may provide a new understanding of intestinal disease pathogenesis that benefits clinical treatment. In this review, we provide an overview of ferroptosis and its underlying mechanisms, then describe its emerging role in intestinal diseases, including intestinal ischaemia/reperfusion (I/R) injury, inflammatory bowel disease (IBD), and colorectal cancer (CRC).
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影响因子：
--
作者：
Ayala A;Muñoz MF;Argüelles S
通讯作者：
Argüelles S
ACSL4 通过塑造细胞脂质成分来决定铁死亡敏感性。
影响因子：
14.8
作者：
Doll S;Proneth B;Tyurina YY;Panzilius E;Kobayashi S;Ingold I;Irmler M;Beckers J;Aichler M;Walch A;Prokisch H;Trümbach D;Mao G;Qu F;Bayir H;Füllekrug J;Scheel CH;Wurst W;Schick JA;Kagan VE;Angeli JP;Conrad M
通讯作者：
Conrad M
影响因子：
4
作者：
Dixon SJ;Winter GE;Musavi LS;Lee ED;Snijder B;Rebsamen M;Superti-Furga G;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
21.3
作者：
Friedmann Angeli JP;Schneider M;Proneth B;Tyurina YY;Tyurin VA;Hammond VJ;Herbach N;Aichler M;Walch A;Eggenhofer E;Basavarajappa D;Rådmark O;Kobayashi S;Seibt T;Beck H;Neff F;Esposito I;Wanke R;Förster H;Yefremova O;Heinrichmeyer M;Bornkamm GW;Geissler EK;Thomas SB;Stockwell BR;O'Donnell VB;Kagan VE;Schick JA;Conrad M
通讯作者：
Conrad M