Sympatho-adrenal morphogenesis regulated by the dorsal aorta.
Sympatho-adrenal morphogenesis regulated by the dorsal aorta.
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交感肾上腺形态发生受背主动脉调节。
DOI：
10.1016/j.mod.2015.07.011
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Y.
中科院分区：
文献类型：
--
作者：
Saito;D. and Takahashi;Y.
自主神经系统由交感神经元和副交感神经元组成，在包括稳态和对外部刺激的反应在内的各种生理功能中起重要作用。我们在这里概述了有关交感神经系统在早期发育过程中如何形成的最新发现，特别关注来自迁移神经嵴细胞的组织的形态发生。神经嵴细胞，最初是多能的，在其通过身体的迁移过程中逐渐指定为交感神经节神经元和肾上腺髓质细胞。重要的是，背主动脉，第一个形成的血管，作为他们的迁移和分化的信号中心。从背主动脉发出的BMP信号对于建立直接作用于迁移细胞的环境线索是必不可少的。这些早期神经血管相互作用的机制为理解自主神经系统功能障碍和畸形引起的疾病提供了见解。
The autonomic nervous system, composed of sympathetic- and para-sympathetic neurons, plays essential roles in a variety of physiological functions including homeostasis and responses to external stimuli. We here present an overview of recent findings concerning how the sympathetic nervous system is formed during the early development, paying particular attention to the morphogenesis of those tissues derived from migrating neural crest cells. Neural crest cells, originally multipotent, are progressively specified to sympathetic ganglia neurons and adrenomedullary cells during their migration through the body. Importantly, the dorsal aorta, the first-forming blood vessel, acts as a signaling center for their migration and differentiation. BMP signals emanating from the dorsal aorta are essential for establishing environmental cues that directly act on the migrating cells. The mechanisms underlying these early neuro-vascular interactions provide insights into understanding diseases caused by malfunctions and malformations of the autonomic nervous system.