Long-term follow-up of polypoidal choroidal vasculopathy after photodynamic therapy with verteporfin
Long-term follow-up of polypoidal choroidal vasculopathy after photodynamic therapy with verteporfin
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DOI：
10.1007/s00417-007-0582-9
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发表时间：
2007-10-01
影响因子：
2.7
通讯作者：
Tano, Yasuo
中科院分区：
文献类型：
--
作者：
Sayanagi, Kaori;Gomi, Fumi;Tano, Yasuo
目的探讨光动力疗法（PDT）治疗后3例息肉状脉络膜血管病变（PCV）的临床特点，设计干预性病例报告。方法回顾性分析我院参加日本黄斑变性相关试验（JAT）的3例PCV患者，采用眼底照相机行吲哚菁绿色血管造影（ICGA）。我们报告的临床特点，这些案件在超过4年的following.Results的平均数PDT治疗是5.7。所有患眼在18个月内视力（VA）改善，荧光素渗漏停止;然而，由于新发或复发性PCV，视网膜下出血和中心凹下积液复发。结论PDT治疗成功的PCV患眼，在长期随访中可能发生新的或复发的PCV。需要定期ICGA来检测脉络膜血管的异常变化。
Purpose To report on the clinical features of three cases of polypoidal choroidal vasculopathy (PCV) during long-term follow-up after photodynamic therapy (PDT).Design Interventional case reports.Methods Among the participants in the Japanese Age-Related Macular Degeneration Trial (JAT) at our hospital, a PCV was seen in three eyes at baseline on retrospective analysis of indocyanine green angiography (ICGA) using fundus camera. We report the clinical features of these cases during more than 4 years follow-up.Results The mean number of PDT treatments was 5.7. Improved visual acuity (VA) and cessation of fluorescein leakage was achieved within 18 months in all eyes; however, subretinal hemorrhage and subfoveal fluid recurred due to new or recurrent PCV. The final VA decreased markedly in two eyes.Conclusions The eyes with PCV, which had been treated successfully with PDT, may have developed new or recurrent PCV during long-term follow-up. Periodical ICGA would be needed to detect abnormal choroidal vascular changes.