Overexpression of nuclear NHERF1 in advanced colorectal cancer: Association with hypoxic microenvironment and tumor invasive phenotype
Overexpression of nuclear NHERF1 in advanced colorectal cancer: Association with hypoxic microenvironment and tumor invasive phenotype
复制标题
DOI：
10.1016/j.yexmp.2012.03.004
复制
发表时间：
2012-06-01
影响因子：
3.6
通讯作者：
Mangia, Annita
中科院分区：
文献类型：
--
作者：
Malfettone, Andrea;Silvestris, Nicola;Mangia, Annita
超过 57% 的结直肠癌 (CRC) 患者在诊断时疾病已发生区域或远处扩散。尽管最近取得了进展，但仍然迫切需要更好地描述晚期结直肠癌的预后标志物。本研究调查了 NHERF1、HIF-1 α 和 TWIST1 的蛋白表达及其在远处正常粘膜（DNM）、肿瘤（T）和邻近正常粘膜（ANM）、淋巴结转移（LNM）和肝转移（LM）中的关系，确定它们作为人类结直肠癌晚期的潜在标志物的作用。 47% 的肿瘤中显示核 NHERF1 过度表达，这与较差的组织学分级显着相关（P=0.0346）。核 NHERF1 在 T、LNM 和 LM 中的表达高于 DNM（P
Over 57% of colorectal cancer (CRC) patients have regional or distant spread of their disease at the time of diagnosis. Despite recent advances, there is a compelling need to better characterize prognostic markers for advanced CRC. The present study investigates protein expression of NHERF1, HIF-1 alpha and TWIST1 and their relationship in distant normal mucosa (DNM), tumor (T) and adjacent normal mucosa (ANM), lymph node metastasis (LNM) and liver metastasis (LM), determining their role as potential markers in advanced stages of human CRC. Overexpression of nuclear NHERF1 was shown in 47% of tumors, which exhibited a significant association with poor histological grade (P=0.0346). Nuclear NHERF1 showed a higher expression in T, LNM and LM than both DNM (P