Association between lung function and cognition among children in a prospective birth cohort study
Association between lung function and cognition among children in a prospective birth cohort study
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DOI：
10.1097/psy.0b013e3181656a5a
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发表时间：
2008-04-01
影响因子：
3.3
通讯作者：
Wright, Rosalind J.
中科院分区：
文献类型：
--
作者：
Suglia, Shakipa Franco;Wright, Robert O.;Wright, Rosalind J.
目的：在东波士顿的母婴吸烟研究中检查儿童肺功能和认知之间的关系，这是一项前瞻性队列研究，纳入了妊娠20周前的妇女和儿童。许多研究已经证明了成人的肺功能和认知之间的关系，但这种关系尚未在儿童中进行研究。方法：在6岁时，儿童完成肺功能检查。在9岁时，进行记忆和学习的广泛评估（WRAML）和考夫曼简明智力测验（K-BIT）。线性回归用于评估认知与肺功能之间的关系。结果：165名儿童的样本包括53%的女孩和52%的西班牙裔。平均（+/-标准差）第一秒用力呼气量（FEV（1））为1.26 +/- 0.2 L;平均用力肺活量（FVC）为1.37 +/- 0.2 L。在多变量回归中，FEV较预期值增加1%与K-BIT的矩阵和复合分量表（p <0.05）以及WRAML的语言和学习分量表（p <0.10）的增加相关。FVC与KBIT的复合和基质分量表以及WRAML的视觉和学习分量表的增加相关（所有p <0.05）。结论：在调整烟草暴露、出生体重和血铅峰值后，肺功能的增强与儿童认知发育的增强相关。肺和认知功能可能在共同的调节过程下运作，因此在发育过程中对许多环境因素具有共同的脆弱性。
Objectives: To examine the relationship between lung function and cognition among children in the Matemal-Infant Smoking Study of East Boston, a prospective cohort of women and children enrolled before 20 weeks of gestation. A number of studies have demonstrated a relationship between lung function and cognition among adults, but this relationship has not been studied among children. Methods: At 6 years of age, children completed lung function tests. At 9 years of age, the Wide Range Assessment of Memory and Learning (WRAML) and Kaufman Brief Intelligence Test (K-BIT) were administered. Linear regression was used to assess the relationship between cognition and lung function. Results: The sample of 165 children included 53% girls and 52% Hispanic. Mean (+/- standard deviation) forced expiratory volume in I second (FEV (1)) was 1.26 +/- 0.2 L; mean forced vital capacity (FVC) was 1.37 +/- 0.2 L. In multivariate regression, a 1% increase from expected FEV, was associated with increases in the matrices and composite subscales of the K-BIT (p < .05), and in the verbal and learning subscales of the WRAML (p < .10). FVC was associated with increases in the composite and matrices subscale of the KBIT and in the visual and learning subscales of the WRAML (all p < .05). Conclusion: Increased lung function was associated with increased cognitive development among children after adjusting for tobacco exposure, birthweight, and peak blood lead. Lung and cognitive function may operate under common regulatory processes and thus have shared vulnerabilities to a host of environmental factors during development.